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Displaying results 11 - 20 of 39 in total
  1. Pathway

    Human Thrombin Action Pathway

    smpdb.ca/view/SMP0126872
    Drug action

    Human thrombin is purified human thrombin, a highly specific serine protease that acts on fibrinogen to fibrin, leading to the formation of a blood clot. … Human thrombin is a platelet-activating factor also known under the brand names Artiss, Evarrest, Evicel, Evithrom, Tachosil, Tisseel and Vistaseal.

    Drugs: Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  2. Pathway

    Antihemophilic Factor Human Action Pathway

    smpdb.ca/view/SMP0126841
    Drug action

    Antihemophilic factor human, also known as Hemofil, Koate, and Wilate is used as factor VIII replacement therapy to treat hemophilia A. … Administered intravenously the antihemophilic factor human replaces the abnormal coagulation factor VIII, acting as a cofactor to activate coagulation factor IX and X.

    Drugs: Calcium · Antihemophilic factor human
    Enzymes: Thrombin, Fibrinogen beta chain
  3. Pathway

    Antihemophilic Factor Human Recombinant Action Pathway

    smpdb.ca/view/SMP0126774
    Drug action

    Antihemophilic factor, human recombinant is administered intravenously and acts to correct coagulation defects, by activating coagulation factor X and IX. … and Factor XIII deficiency.

    Drugs: Antihemophilic factor, human recombinant · Calcium
    Enzymes: Thrombin, Fibrinogen beta chain
  4. Pathway

    Coagulation Factor VII Human Action Pathway

    smpdb.ca/view/SMP0126839
    Drug action

    Coagulation factor VII human is a coagulation factor also known as Balfaxar, Beriplex, Kcentra and Octaplex to treat hemophilia and Glanzmann's thrombasthenia. … It is administered intravenously it acts in combination with tissue factor activating coagulation factor VIIa, which goes on to subsequently activate coagulation factor X and IX leading to blood clotting

    Drugs: Calcium · Coagulation factor VII human
    Enzymes: Thrombin, Fibrinogen beta chain
  5. Target

    Fibrinogen

    go.drugbank.com/bio_entities/BE0009672
    TargetHumans

    Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. … Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix.

    Polypeptides: Fibrinogen alpha chain, Fibrinogen beta chain
  6. Target

    Fibrinogen alpha chain

    go.drugbank.com/bio_entities/BE0000538
    TargetHumans

    Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. … May also facilitate the immune response via both innate and T-cell mediated pathways

    Polypeptides: Fibrinogen alpha chain
  7. Target

    Fibrinogen beta chain

    go.drugbank.com/bio_entities/BE0002091
    TargetHumans

    Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. … May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways

    Polypeptides: Fibrinogen beta chain
  8. Drug

    Efmoroctocog alfa

    go.drugbank.com/drugs/DB11607
    ApprovedInvestigational

    VIII, but does not contain the B-domain, which has no known biological function, and [DB13192], which is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. … Efmoroctocog alfa is a first commercially available rFVIII-Fc fusion protein (rFVIIIFc) where the conjugated molecule of rFVIII to polyethylene glycol is covalently fused to the dimeric Fc domain of human

    Categories: Human Antihemophilic Factors
  9. Drug

    Dabigatran etexilate

    go.drugbank.com/drugs/DB06695
    ApprovedInvestigational

    Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor [dabigatran].

    Categories: Blood and Blood Forming Organs
  10. Drug

    Simoctocog alfa

    go.drugbank.com/drugs/DB09108
    Approved

    Full human post-translational modifications via elimination of potentially immunogenic glycosylation patterns found in non-human cell lines led to decreased immunogenicity and longer half-life [A31525] … Simoctocog alfa is a fourth-generation BDD FVIII product made in the human embryonic kidney (HEK) cell line.

    Categories: Amino Acids, Peptides, and Proteins