Fibrinogen alpha chain

BE0000538ProteinHumansFGA

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. It is acted on by 16 drugs in DrugBank.

Gene name
FGA
UniProtKB entry
P02671Swiss-Prot
Cellular location
Secreted
Residues / weight
866 residues · 94,972 Da

Resolves to

Protein
UniProtP02671UniProt nameFIBA_HUMAN
Gene
HGNCHGNC:3661NCBI Gene2243GenBank13591824GeneCardsFGA
Pharmacology
KEGGhsa:2243
Structure
PDB1BBRPDB1DM4PDB1FPH
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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29GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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65+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fibrinogen alpha chain, how selective are they, and which programs against it are still in active trials?

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