Search

Displaying results 11 - 14 of 14 in total
  1. Target

    Nucleotide triphosphate diphosphatase NUDT15

    go.drugbank.com/bio_entities/BE0009809
    EnzymeHumans

    Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:22556419

    Synonyms: Nucleoside diphosphate-linked to another moiety X hydrolase 15
  2. Target

    E3 ubiquitin ligase TRAF3IP2

    go.drugbank.com/bio_entities/BE0011632
    TargetHumans

    Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). … Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B

    Synonyms: Connection to IKK and SAPK/JNK
  3. Target

    E3 ubiquitin-protein ligase HUWE1

    go.drugbank.com/bio_entities/BE0016469
    TargetHumans

    Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). … Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity).

    Synonyms: Homologous to E6AP carboxyl terminus homologous protein 9
  4. Target

    Zinc finger and BTB domain-containing protein 7A

    go.drugbank.com/bio_entities/BE0012406
    TargetHumans

    Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). … Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity).

    Synonyms: Factor that binds to inducer of short transcripts protein 1