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Esomeprazole Action Pathway (Old)
smpdb.ca/view/SMP0000225Drug actionThis active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus.
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Pantoprazole Action Pathway
smpdb.ca/view/SMP0000228Drug actionThis active metabolite then binds covalently to the potassium-transporting ATPase protein subunits, found at the secretory surface of the gastric parietal cell, preventing any stimulus.
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Pirenzepine Action Pathway
smpdb.ca/view/SMP0000246Drug actionPirenzepine (also known as Gastrozepin) is a selective antagonist (antimuscarinic) that will inhibit the muscarinic acetylcholine receptor M3 inside the stomach. Binding of pirenzepine on the receptor will decrease the level of exertion ...
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Betazole Action Pathway
smpdb.ca/view/SMP0000736Drug actionBetazole, also known as ametazole and Histalog, is a histamine H2 agonist that causes an increase in gastric acid secretion. Betazole is commonly used to evaluate acid production. Betazole binds to the H2 receptor to enhance the G protei...
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Famotidine Action Pathway
smpdb.ca/view/SMP0000231Drug actionFamotidine (also known as Pepcid) can bind and inhibit histamine H2 receptor on parietal cell's basolateral membrane. Binding of famotidine can effectively inhibit the histamine effects, which lead to reduced nocturnal gastric acid and b...
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Cimetidine Action Pathway
smpdb.ca/view/SMP0000232Drug actionCimetidine, sold as Tagamet, is a compound related to histamine. It is a H2 antagonist drug, also called H2RAs or H2 blockers, and was the first of this class to be discovered. H2 antagonist drugs compete with histamine to bind to the hi...
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1Omeprazole Action Pathway
smpdb.ca/view/SMP0122674Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions.
Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1Esomeprazole Action Pathway
smpdb.ca/view/SMP0123196Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions.
Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1Lansoprazole Action Pathway
smpdb.ca/view/SMP0123261Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions.
Enzymes: Chloride anion exchanger, Potassium-transporting ATPase alpha chain 1Nizatidine Action Pathway
smpdb.ca/view/SMP0000233Drug actionNizatidine (also known as Axid or Acinon) is a histamine H2 receptor antagonist, that can bind to histamine H2 receptor on gastric basolateral membrane, which can reduce the gastric acid response. Blocking of histamine binding to histami...
Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1