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Displaying results 11 - 20 of 224 in total
  1. Drug

    Calcium citrate

    go.drugbank.com/drugs/DB11093
    ApprovedInvestigational

    Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.

    Salts: Calcium citrate malate
  2. Drug

    Venglustat

    go.drugbank.com/drugs/DB14966
    Investigational

    Venglustat is under investigation in clinical trial NCT01674036 (Safety, Tolerability and Pharmacokinetics of Genz-682452 in Healthy Men).

    Salts: Venglustat malate
  3. Drug

    Citrulline

    go.drugbank.com/drugs/DB00155
    InvestigationalNutraceutical

    Citrulline is an amino acid. It is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. Its name is deri...

    Salts: Citrulline malate
  4. Drug

    Famitinib

    go.drugbank.com/drugs/DB11741
    Investigational

    Famitinib has been used in trials studying the treatment of Colorectal Cancer, Renal Cell Cancer, Colorectal Cancer Recurrent, Colorectal Cancer Metastatic, and Metastatic Renal Cell Cancer, among others.

    Salts: Famitinib malate
  5. Drug

    Sitagliptin

    go.drugbank.com/drugs/DB01261
    ApprovedInvestigational

    Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication ...

    Salts: Sitagliptin malateMixtures: Teva-sitagliptin Malate / Metformin, Teva-sitagliptin Malate / Metformin
  6. Drug

    Amonafide

    go.drugbank.com/drugs/DB05022
    Investigational

    Amonafide is a substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.

    Salts: Amonafide L-malate
  7. Drug

    Dexchlorpheniramine maleate

    go.drugbank.com/drugs/DB09555
    Approved

    Dexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.

    Synonyms: Dexchlorpheniramine maleateMixtures: Dexchlorpheniramine Maleate, Phenylephrine HCl, Chlophedianol Hydrochloride, Dexchlorpheniramine Maleate, and Pseudoephedrine Hydrochloride
  8. Target

    Malate dehydrogenase

    go.drugbank.com/bio_entities/BE0001267
    TargetChloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)

    Catalyzes the reversible oxidation of malate to oxaloacetate.

    Polypeptides: Malate dehydrogenaseFunction: L-malate dehydrogenase activity
  9. Target

    Malate synthase G

    go.drugbank.com/bio_entities/BE0001750
    TargetMycobacterium tuberculosis

    Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.

    Polypeptides: Malate synthase G
  10. Pathway

    Malate-Aspartate Shuttle

    smpdb.ca/view/SMP0000129
    Metabolic

    When the malate gets inside the membrane,the energy inside of malate is taken out by creating NADH from NAD+, which regenerates oxaloacetate. … The malate-aspartate shuttle is needed as the inner membrane is not permeable to NADH or NAD+, but is permeable to the ions that attach to malate.

    Drugs: Pyridoxal phosphate · Aspartic acid · Glutamic acid · NADH · Calcium · Oxogluric acid
    Enzymes: Malate dehydrogenase, mitochondrial, Mitochondrial 2-oxoglutarate/malate carrier protein