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Acebutolol
go.drugbank.com/drugs/DB01193ApprovedInvestigationalA cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 3'-acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide, N-(3-acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamidePerphenazine
go.drugbank.com/drugs/DB00850ApprovedInvestigationalAn antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Mixtures: PMS-levazine 4/25 Tab, โพลีบอน 4-10Categories: Heterocyclic Compounds, 3-Ring, Cytochrome P-450 SubstratesVismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigational[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-Avanafil
go.drugbank.com/drugs/DB06237ApprovedAvanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. … In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: (S)-4-(3-Chloro-4-methoxybenzylamino)-2-(2-hydroxymethylpyrrolidin-1-yl)-N-pyrimidin-2-ylmethyl-5-pyrimidinecarboxamideBrompheniramine
go.drugbank.com/drugs/DB00835ApprovedHistamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Mixtures: M-end Wc, M-end PECategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSeladelpar
go.drugbank.com/drugs/DB12390ApprovedInvestigationalSeladelpar is a peroxisome proliferator-activated receptor (PPAR)-delta (δ) agonist. Seladelpar is a single enantiomer of the R-configuration. … [L51149] On August 14, 2024, seladelpar was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis,[L51154] which is a condition associated with aberrant bile acid metabolism
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: (R)-2-(4-((2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)-THIO)-2-METHYLPHENOXY)ACETIC ACID, ((4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENYL)OXY)ACETIC ACIDPindolol
go.drugbank.com/drugs/DB00960ApprovedInvestigational[A231064] Pindolol was granted FDA approval on 3 September 1982.[L32348] … Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: 1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)-propan-2-ol, 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-olDopamine
go.drugbank.com/drugs/DB00988ApprovedInvestigationalDopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Mixtures: Dopamine HCl 3.2mg/ml Dextrose 5% Inj USP, Dopamine HCl 1.6mg/ml Dextrose 5% Inj USPCategories: Monoamine Oxidase A Substrates, Selective Beta 1-adrenergic AgonistsPhenprocoumon
go.drugbank.com/drugs/DB00946ApprovedInvestigationalWithdrawnCoumarin derivative that acts as a long-acting oral anticoagulant.
Categories: 4-Hydroxycoumarins, Heterocyclic Compounds, 2-RingSynonyms: 4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one, 4-Hydroxy-3-(1-phenylpropyl)-2H-1-benzopyran-2-oneAcenocoumarol
go.drugbank.com/drugs/DB01418ApprovedInvestigationalAcenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. … This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, IX and X, and interferes with coagulation.
Categories: 4-Hydroxycoumarins, Heterocyclic Compounds, 2-RingSynonyms: 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one, 4-Hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-2H-1-benzopyran-2-one