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Torasemide
go.drugbank.com/drugs/DB00214ApprovedInvestigationalTorasemide is a high-ceiling loop diuretic.[A174463] Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesSynonyms: 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea, N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamideChlorpropamide
go.drugbank.com/drugs/DB00672ApprovedWithdrawnChlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy (UKPDS-33). … Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor.
Categories: Alimentary Tract and Metabolism, Genito Urinary System and Sex HormonesSynonyms: 1-propyl-3-(p-chlorobenzenesulfonyl)urea, n-propyl-N'-(p-chlorobenzenesulfonyl)ureaCarbomer homopolymer type C
go.drugbank.com/drugs/DB14091InvestigationalCarbomer homopolymer type C is a high molecular polyanionic substance tested for antiulcerogenic activity.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Carbomer homopolymer type C, Carbomer homopolymer type C (allyl pentaerythritol crosslinked)Florquinitau (18F)
go.drugbank.com/drugs/DB19215ApprovedInvestigational[L64052] After intravenous injection, florquinitau F 18 crosses the blood-brain barrier and accumulates in brain regions containing tau NFTs, allowing their distribution to be visualized and interpreted … Florquinitau F 18 is a radioactive diagnostic drug used as a fluorine-18–labeled positron emission tomography (PET) tracer.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: 6-fluoro-3-(1h-pyrrolo(2,3-c)pyridin-1-yl)isoquinolin-5-amine, 5-isoquinolinamine, 6-(fluoro-18f)-3-(1h-pyrrolo(2,3-c)pyridin-1-yl)-Ilorasertib
go.drugbank.com/drugs/DB11694InvestigationalIlorasertib has been used in trials studying the treatment of Myelodysplasia, Solid Neoplasm, Advanced Cancers, Advanced Solid Tumors, and Acute Myelogenous Leukemia, among others.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-(4-(4-amino-7-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)phenyl)-3-(3-fluorophenyl)urea, 1-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridine-3-yl}phenyl)-3-(3-fluorophenyl)urea)Cytarabine
go.drugbank.com/drugs/DB00987ApprovedInvestigationalCytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. … It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Synonyms: Ara C, Ara-CInternational brands: Ara-C, Cytosar-UORM-13070 C-11
go.drugbank.com/drugs/DB15324InvestigationalORM-13070 C-11 is under investigation in clinical trial NCT00735774 (Suitability of 11C-ORM-13070 as a PET Tracer).
Categories: Heterocyclic Compounds, 1-RingC-1027 Aromatized chromophore
go.drugbank.com/drugs/DB03933ExperimentalSynonyms: C-1027 Aromatized chromophoreMianserin
go.drugbank.com/drugs/DB06148ApprovedWithdrawnA tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favour of [mirtazapine].
Categories: Heterocyclic Compounds, 3-Ring, Cytochrome P-450 SubstratesSynonyms: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine