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Displaying results 191 - 200 of 449 in total
  1. Drug

    Sabestomig

    go.drugbank.com/drugs/DB19326
    Investigational

    Sabestomig is under investigation in clinical trial NCT05216835 (Safety and Preliminary Efficacy Assessment of AZD7789 in Patients With Relapsed or Refractory Classical Hodgkin Lymphoma).

    Synonyms: Immunoglobulin G1 [239-phenylalanine,240-glutamic acid,336-serine,354-cysteine,371-serine,373-alanine,412-valine], bispecific, anti-(human programmed cell death protein 1) (human-Mus musculus clone LO115, Immunoglobulin G1-kappa/lambda, anti-[Homo sapiens PDCD1 (programmed cell death 1, PD1, PD-1, CD279) and HAVCR2 (hepatitis A virus cellular receptor 2, T cell immunoglobulin and mucin domains family member
  2. Drug

    Sirexatamab

    go.drugbank.com/drugs/DB17515
    Investigational

    Synonyms: Immunoglobulin g4 (224-proline,233-alanine,234-alanine), anti-(human dickkopf-1) (human-mus musculus monoclonal dkn-01 .gamma.4-chain), disulfide with human-mus musculus monoclonal dkn-01 .kappa., Anti-dkk-1 monoclonal antibody ly2812176
  3. Drug

    Cantuzumab mertansine

    go.drugbank.com/drugs/DB17239
    Experimental

    Synonyms: Immunoglobulin g1, anti-(mucin canag) (human-mouse monoclonal c242 heavy chain), disulfide with human-mouse monoclonal c242 light chain, dimer, compound with n(sup 2')-deacetyl-n(sup 2')-(3-mercapto-1-, Immunoglobulin g1, anti-(mucin canag) (human-mouse monoclonal c242 heavy chain), disulphide with human-mouse monoclonal c242 light chain, dimer, compound with n(sup 2')-deacetyl-n(sup 2')-(3-mercapto-1Categories: Immunoglobulins
  4. Drug

    Talditercept alfa

    go.drugbank.com/drugs/DB16337
    Investigational

    Talditercept alfa is under investigation in clinical trial NCT03039686 (Clinical Trial to Evaluate the Efficacy, Safety, and Tolerability of RO7239361 in Ambulatory Boys With Duchenne Muscular Dystrophy).

    Synonyms: Immunoglobulin g1 (human fc fragment) fusion protein with peptide (synthetic 17-amino acid linker) fusion protein with adnectin, anti-(human growth differentiation factor 8) (human clone bms-986089 fibronectin, Bivalent Anti-Human Myostatin Adnectin-Igg1
  5. Drug

    Tobevibart

    go.drugbank.com/drugs/DB18986
    Investigational

    Tobevibart is under investigation in clinical trial NCT05612581 (A Platform Study to Evaluate Investigational Therapies in Chronic Hepatitis B Infection).

    Synonyms: Immunoglobulin G1 [238-alanine,332-leucine,334-glutamic acid,430-leucine,436-serine], anti-(hepatitis B virus surface antigen) (human monoclonal VIR-3434 γ1-chain), disulfide with human monoclonal VIR-, 3434 λ-chain, dimer
  6. Drug

    Mezagitamab

    go.drugbank.com/drugs/DB16370
    Investigational

    Mezagitamab is under investigation in clinical trial NCT04278924 (Study to Evaluate Safety, Tolerability, and Efficacy of TAK-079 in Participants With Persistent/chronic Primary Immune Thrombocytopenia).

    Synonyms: IMMUNOGLOBULIN G1, ANTI-(HUMAN CD38 ANTIGEN) (HUMAN MONOCLONAL AB79 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AB79 .LAMBDA.-CHAIN, DIMER, IMMUNOGLOBULIN G1-LAMBDA, ANTI-(HOMO SAPIENS ADP-RIBOSYL CYCLASE/CYCLIC ADP-RIBOSE HYDROLASE 1 (2'-PHOSPHO-ADP-RIBOSYL CYCLASE, ANTIGENE CD38))HUMANIZED MONOCLONAL ANTIBODY.GAMMA.1 HEAVY CHAIN HUMANIZED
  7. Drug

    Acazicolcept

    go.drugbank.com/drugs/DB18410
    Investigational

    Synonyms: 1-122-INDUCIBLE COSTIMULATORY LIGAND PROTEIN (52-HISTIDINE,57-TYROSINE,100-ARGININE) (HUMAN) FUSION PROTEIN WITH SYNTHETIC PEPTIDE LINKER (GGGGSGGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN .GAMMA, HUMAN INDUCIBLE T-CELL CO-STIMULATOR LIGAND (ICOS LIGAND) N-TERMINAL FRAGMENT (1-122) (VARIANT (N52>H, N57>Y, Q100>R), FUSED VIA PEPTIDYL LINKER 123GGGGSGGGGS132 TO A HUMAN IMMUNOGLOBULIN G1 FC FRAGMENT
  8. Drug

    Englumafusp alfa

    go.drugbank.com/drugs/DB19341
    Investigational

    and in Combination With Glofitamab Following a Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/refractory B-cell Non-hodgkin's Lymphoma). … Englumafusp alfa is under investigation in clinical trial NCT04077723 (A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab

    Synonyms: humanized immunoglobulin G1-kappa anti-(human B-lymphocyte antigen CD19) modified heterodimer where the heavy and light chain variable regions of one arm have been substituted by three subunits of human, fusion protein with immunoglobulin G1 [497-ala
  9. Drug

    Inolimomab

    go.drugbank.com/drugs/DB15628
    Investigational

    It has thus far offered similar efficacy to other monoclonal antibody options, though it may carry a higher risk of infections.[A241385]

    Categories: Immunoglobulins, Receptors, Interleukin-2Synonyms: Immunoglobulin G1, anti-(human interleukin 2 receptor alpha-chain) (mouse monoclonal B-B10 gammal-chain), disulfide with mouse monoclonal B-B10 kappa-chain, dimer
  10. Drug

    Inbakicept

    go.drugbank.com/drugs/DB16479
    Investigational

    Inbakicept is a dimeric human IL-15 receptor α (IL-15Rα) sushi domain/human IgG1 Fc fusion protein. … It is one of the active ingredients in Anktiva, a combination product also containing [nogapendekin alfa], where a single inbakicept is complexed with two nogapendekin alfa components.

    Synonyms: CHAIN (HUMAN SUSHI DOMAIN-CONTAINING FRAGMENT) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN FC FRAGMENT), DIMER, INTERLEUKIN 15 RECEPTOR SUBUNIT ALPHA (HUMAN IL15R.ALPHA.) (1-65)-PEPTIDE (SUSHI DOMAIN-CONTAINING) FUSION PROTEIN WITH HUMAN IMMUNOGLOBULIN G1 FC FRAGMENT (232 C-TERMINAL RESIDUES) (66-297) (HOMO SAPIENS