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  1. Drug

    Milciclib Maleate

    go.drugbank.com/drugs/DB16232
    Investigational

    Milciclib Maleate is under investigation in clinical trial NCT01301391 (Study of Oral PHA-848125AC in Patients With Malignant Thymoma Previously Treated With Multiple Lines of Chemotherapy).

  2. Drug

    alpha-Hydroxylinoleic acid

    go.drugbank.com/drugs/DB16027
    Investigational

    alpha-Hydroxylinoleic acid is under investigation in clinical trial NCT04431258 (ABTL0812 in Combination With FOLFIRINOX for First-line Treatment of Metastatic Pancreatic Study).

  3. Drug

    ADH-1

    go.drugbank.com/drugs/DB05485
    Investigational

    ADH-1 may have utility in a wide variety of cancers as N-cadherin is overexpressed in a variety of tumors. … ADH-1 is currently in clinical development in a combination program with a range of chemotherapeutic agents to investigate the synergistic effects noted in our preclinical models.

    Synonyms: l-cysteinamide, n-acetyl-l-cysteinyl-l-histidyl-l-alanyl-l-valyl-, cyclic (1-5)-disulfide
  4. Drug

    Amsilarotene

    go.drugbank.com/drugs/DB21085
    Investigational

    Amsilarotene is under investigation in clinical trial NCT00687596 (Study of TAC-101 as Second Line Treatment in Patients With Advanced Hepatocellular Carcinoma Who Received Sorafenib as First Line Therapy … Amsilarotene is a small molecule drug. The usage of the INN stem '-arotene' in the name indicates that Amsilarotene is a arotinoid derivative.

  5. Drug

    AVB-001

    go.drugbank.com/drugs/DB18452
    Investigational

    AVB-001 is an encapsulated, engineered human ARPE-19 cell line that constitutively expresses the native human IL-2 cytokine

  6. Drug

    Loxoprofen

    go.drugbank.com/drugs/DB09212
    ApprovedInvestigational

    It is marketed under the trade name Loxonin in Brazil, Mexico and Japan by Sankyo, as Loxomac in India, and as Oxeno in Argentina. … A transdermal preparation was approved for use in Japan in January 2006.

  7. Drug

    Estradiol dienanthate

    go.drugbank.com/drugs/DB13955
    ApprovedVet approvedWithdrawn

    Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. … Estradiol dienanthate is not currently available in any commercially available products in Canada or the US.

  8. Drug

    Peanut oil

    go.drugbank.com/drugs/DB13964
    ApprovedWithdrawn

    [L2242] Under Health Canada, it is approved as an active ingredient in over-the-counter combination products.[L1113] … Peanut oil is derived from _Arachis hypogaea_ which can be found in South America, Mexico, and Centro America.

  9. Drug

    Yohimbine

    go.drugbank.com/drugs/DB01392
    ApprovedInvestigationalVet approvedWithdrawn

    Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac.

    Categories: Drugs Used in Erectile Dysfunction
  10. Drug

    Ritlecitinib

    go.drugbank.com/drugs/DB14924
    ApprovedInvestigational

    In June 2023, it was approved by the FDA for the treatment of severe alopecia areata in adults and adolescents 12 years and older.[L47092,L47127] It was further approved by the EMA in September 2023. … Ritlecitinib (PF-06651600) is a highly selective inhibitor of Janus kinase 3 (JAK3) and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family.