Search

Displaying results 2011 - 2020 of 8171 in total
  1. Drug

    Ranirestat

    go.drugbank.com/drugs/DB05327
    Investigational

    Ranirestat is a structurally novel and stereospecifically potent aldose reductase (AKR1B; EC 1.1.1.21) inhibitor, which contains a succinimide ring that undergoes ring-opening at physiological pH levels

  2. Drug

    Topotecan

    go.drugbank.com/drugs/DB01030
    ApprovedInvestigational

    An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.

    Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A Inhibitors
  3. Drug

    Potassium cation

    go.drugbank.com/drugs/DB01345
    Approved

    Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity. … The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential—a "spike" of electrical discharge.

  4. Drug

    Metergoline

    go.drugbank.com/drugs/DB13520
    Approved

    [A27181] Its use has been studied in various clinical settings such as a treatment for seasonal affective disorder, prolactin hormone regulation due to its inhibitory effect on prolactin release,[A27182 … Metergoline is an ergot-derived psychoactive drug that acts as a ligand for serotonin and dopamine receptors.

  5. Drug

    Tuparstobart

    go.drugbank.com/drugs/DB19118
    Investigational

    Tuparstobart is under investigation in clinical trial NCT05287113 (Study of Retinfanlimab in Combination With INCAGN02385 and INCAGN02390 as First-line Treatment in Participants With Pd-l1-positive (CPS

    Synonyms: Immunoglobulin G1 [301-alanine,de-C-terminal-lysine], anti-(human lymphocyte activation gene-3 protein) (human-Mus musculus monoclonal INCAGN02385 γ1-chain), disulfide with human-Mus musculus monoclonal
  6. Drug

    Axicabtagene ciloleucel

    go.drugbank.com/drugs/DB13915
    ApprovedInvestigational

    can produce cytokines that efficiently kill leukemic cells _in vitro_. … Axicabtagene ciloleucel is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy.

    Synonyms: Autologous T cells transduced with retroviral vector encoding an anti-CD-19 CD28/CD3-zeta chimeric antigen receptor
  7. Drug

    Selenomethionine

    go.drugbank.com/drugs/DB11142
    ApprovedInvestigational

    It can be produced from post-structural modifications. … *In vivo*, selenomethionine plays an essential role in acting as an antioxidant, where it depletes reactive oxygen species (ROS) and aids in the formation and recycling of glutathione, another important

    Mixtures: Vital-D Rx, RenaPlex-D
  8. Drug

    Vortioxetine

    go.drugbank.com/drugs/DB09068
    ApprovedInvestigational

    agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. … Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD).

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  9. Drug

    Calcium ascorbate

    go.drugbank.com/drugs/DB14483
    ApprovedNutraceutical

    Mixtures: PM Caps, Supplements De Vitamines Et Mineraux
  10. Target

    Beta-ketoacyl-[acyl-carrier-protein] synthase III

    go.drugbank.com/bio_entities/BE0000558
    TargetEscherichia coli (strain K12)

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role...

    Synonyms: KAS III