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Enalaprilat
go.drugbank.com/drugs/DB09477ApprovedInvestigationalUsed in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II. … Enalaprilat is poorly orally available and is therefore only available as an intravenous injection for the treatment of hypertension when oral therapy is not possible.
Betibeglogene autotemcel
go.drugbank.com/drugs/DB16900ApprovedInvestigationaldonor due to the risks of graft rejection, graft-versus-host disease, and other treatment-related toxic effects. … Betibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene (β<sup>A-T87Q</sup>-globin) to hematopoietic stem cells in order to treat β-thalassemia.
Protamine sulfate
go.drugbank.com/drugs/DB09141ApprovedInvestigationalSince it's earliest discovery in salmon rine sperm heads in the late 1800's to its formal introduction via US FDA approval in 1939, protamine sulfate has occupied an important therapeutic niche as perhaps … The agent elicits this heparin reversal predominantly via the formation of an inactive complex between the anionic nature of heparin and its own cationic state [A174778, A174781, L5371].
Products: PROMIN 5000 IU/5 ML I.V. ENJEKSIYONLUK ÇÖZELTI IÇEREN AMPULFluorescein
go.drugbank.com/drugs/DB00693ApprovedInvestigationalA phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has ...
Synonyms: D&C Yellow No. 7, D and C Yellow No. 7Rabies immune globulin, human
go.drugbank.com/drugs/DB11603ApprovedIf IMOGAM Rabies Pasteurized is not administered as recommended at the initiation of the post-exposure rabies vaccine series, it can be administered up to eight days following the first dose of the rabies … Recommendations for passive and/or active immunization after exposure to an animal suspected of having rabies have been outlined by the National Advisory Committee on Immunization (NACI), the Advisory
Products: Hyperrab S/d, BERIRAB(R) PDesipramine
go.drugbank.com/drugs/DB01151ApprovedThe antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, desipramine does not affect mood or arousal, but may cause sedation.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTolrestat
go.drugbank.com/drugs/DB02383ApprovedWithdrawnWhile it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval. … Tolrestat (INN) (AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications.
Equine Botulinum Neurotoxin A Immune FAB2
go.drugbank.com/drugs/DB13900ApprovedEquine Botulinum Neurotoxin A Immune FAB2 is composed of a mixture of immune globulin fragments purified from plasma of horses that were previously immunized with botulinum toxin serotype A. It is intravenously administered for the treat...
Vortioxetine
go.drugbank.com/drugs/DB09068ApprovedInvestigationalagonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. … Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesMycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III
go.drugbank.com/bio_entities/BE0001723TargetMycobacterium tuberculosisCatalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role...
Synonyms: KAS III