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Phenelzine
go.drugbank.com/drugs/DB00780ApprovedInvestigationalPhenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. … It is currently approved under prescription by the name of Nardil.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 CYP2E1 InducersCalcitriol
go.drugbank.com/drugs/DB00136ApprovedInvestigationalNutraceuticalIt is produced in the body after series of conversion steps of 7-dehydrocholesterol from exposure to UV light. 7-dehydrocholesterol is converted to [DB00169] (vitamin D3) in the skin, which is then converted … [DB00146] undergoes hydroxylation to form calcitriol via 1α-hydroxylase (CYP27B1) activity [A26353]. Calcitriol is considered to be the most potent metabolite of vitamin D in humans [A3366].
Synonyms: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol, (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triolCategories: Vitamin D and Analogues, Cytochrome P-450 SubstratesSafrazine
go.drugbank.com/drugs/DB09253ApprovedWithdrawnSafrazine is a member of the hydrazine family with non-selective and irreversible inhibitor effects against monoamine oxidases. In 1960, it was used as an antidepressant but it is now discontinued.
Categories: Heterocyclic Compounds, 1-Ring, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromePegloticase
go.drugbank.com/drugs/DB09208ApprovedInvestigational[L42425] Pegloticase has a longer terminal elimination half-life thanks to the addition of a polyethylene glycol (PEG) group. … Pegloticase is a porcine recombinant PEGylated uricase indicated for the treatment of chronic gout in adult patients that do not respond to other types of therapies.
Categories: Compounds used in a research, industrial, or household settingResmetirom
go.drugbank.com/drugs/DB12914ApprovedInvestigationalOn March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD … [L50336] Thyroid hormones directly regulate lipid metabolism in the liver; thus, impaired thyroid function, such as low serum thyroid hormone levels, is often observed in NAFLD.
Synonyms: 1,2,4-Triazine-6-carbonitrile, 2-[3,5-dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-, 2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrileCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingEsculin
go.drugbank.com/drugs/DB13155ApprovedThese are carbohydrate derivatives in which a sugar group is bonded through its anmoeric carbonA to another group via a C-, S-,N-,O-, or Se- glycosidic bond. … Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica
Synonyms: 6-(beta-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one, esculetin 6-β-D-glucosideCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingCitric acid
go.drugbank.com/drugs/DB04272ApprovedInvestigationalNutraceuticalVet approvedA key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. … Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.
Mixtures: E-Z-gas II, E-Z-GAS II GRANULESCategories: Compounds used in a research, industrial, or household settingVortioxetine
go.drugbank.com/drugs/DB09068ApprovedInvestigationalMore specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B … Some serotonin receptors seem to play a relatively neutral or insignificant role in the regulation of mood, but others, such as 5-HT1A autoreceptors and 5-HT7 receptors, appear to play an oppositional
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesProducts: KELAC 5 MG, KELAC® 10MGSelexipag
go.drugbank.com/drugs/DB11362ApprovedInvestigationalPAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. … Marketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT-333679 (MRE-269), act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPralidoxime
go.drugbank.com/drugs/DB00733ApprovedInvestigationalVet approvedPralidoxime is an antidote to organophosphate pesticides and chemicals. … Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme.
Synonyms: 2-PAMCategories: Compounds used in a research, industrial, or household setting