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Mavorixafor
go.drugbank.com/drugs/DB05501ApprovedInvestigationalmavorixafor is being investigated in these conditions. … [L50647] WHIM syndrome is caused by mutations in the _CXCR4_ gene, which leads to overactivation of CXCR4 signalling pathways.[A263652] Mavorixafor prevents the activation of CXCR4.
Synonyms: 1,4-BUTANEDIAMINE, N-(1H-BENZIMIDAZOL-2-YLMETHYL)-N-((8S)-5,6,7,8-TETRAHYDRO-8-QUINOLINYL)-Luspatercept
go.drugbank.com/drugs/DB12281ApprovedInvestigational[A187829,L42455] It was first approved for use in the United States in November 2019 under the brand name Reblozyl® for the treatment of anemia in patients with beta thalassemia who require regular blood … [L42455] Luspatercept is novel in that it ameliorates anemia via action on late-stage erythropoiesis, in contrast to typical erythropoiesis-stimulating agents (ESAs), such as [darbepoetin alfa] and [epoetin
Sucralfate
go.drugbank.com/drugs/DB00364ApprovedInvestigationalIt is sold under many brands and is available in both tablet and suspension forms. It was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form [L6073, L6076]. … , peptic ulcer disease, stress ulcer, in addition to dyspepsia [A177655].
Cimetidine
go.drugbank.com/drugs/DB00501ApprovedInvestigationalIt also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
Synonyms: N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine, N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidineProducts: Cimetidine in Sodium Chloride, Gen-cimetidine Tablets 200mgFospropofol
go.drugbank.com/drugs/DB06716ApprovedIllicitInvestigationalWithdrawnFDA approved in December 2008. Fospropofol is a Schedule IV controlled substance in the United States under the Controlled Substances Act. … Fospropofol is a water soluble prodrug and is converted to propofol in the liver. Fospropofol is a short acting hypnotic/sedative/anesthetic agent.
Pepsin
go.drugbank.com/drugs/DB13198ApprovedWithdrawnPepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products [L2358]. … Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach acid, causes nutrients including meat or coagulated egg whites to dissolve.
Trimethoprim
go.drugbank.com/drugs/DB00440ApprovedInvestigationalVet approvedTrimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it … [L11893] Trimethoprim is often used in combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a monotherapy in the treatment and/or prophylaxis of
Mixtures: COTRIM E RATIO 480MG/5ML, EUSAPRIM E SUSPENS F ERWFesoterodine
go.drugbank.com/drugs/DB06702ApprovedFesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome.
Chloroprocaine
go.drugbank.com/drugs/DB01161ApprovedInvestigationalChloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. … [A252952] Chloroprocaine can be given as an injection, and is available in formulations with and without methylparaben as a preservative.
Benzoic acid
go.drugbank.com/drugs/DB03793ApprovedInvestigationalThis leads to excretion of these amino acids and a decrease in ammonia levels. Recent research shows that sodium benzoate may be beneficial as an add-on therapy (1 gram/day) in schizophrenia. … It is conjugated to GLYCINE in the liver and excreted as hippuric acid.
Mixtures: POLY-N OINTMENTCategories: Compounds used in a research, industrial, or household setting