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Displaying results 2091 - 2100 of 10000 in total
  1. Drug

    Mestranol

    go.drugbank.com/drugs/DB01357
    ApprovedWithdrawn

    The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.

    Mixtures: LUTORAL-E, Norinyl 1/50 28 TabCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates
  2. Pathway

    Disopyramide Cardiac Action Pathway

    smpdb.ca/view/SMP0126247
    Drug action

    Disopyramide is a class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. It can be found under the brand names Norpace and Rythmodan. A class I anti-arrhythmic agent (one that interferes directly with the d...

    Drugs: Disopyramide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  3. Pathway

    Mexiletine Action Pathway (New)

    smpdb.ca/view/SMP0126263
    Drug action

    The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. … Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart.

    Drugs: Mexiletine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  4. Pathway

    Procainamide Action Pathway (New)

    smpdb.ca/view/SMP0126265
    Drug action

    Phenytoin slows the rate of rise in the pacemaker potential and shortens the plateau phase of atrial and ventricular myocytes as well as purkinje fibre cells as they have 'fast' action potential.

    Drugs: Procainamide · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  5. Pathway

    Moricizine Action Pathway

    smpdb.ca/view/SMP0126950
    Drug action

    This results in a slowed atrioventricular nodal and His-Purkinje conduction, which decreases excitability conduction velocity, and automaticity.

    Drugs: Moricizine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2
  6. Drug

    Meglumine

    go.drugbank.com/drugs/DB09415
    ApprovedInvestigational

    Synonyms: N-methyl-D-glucamine, 1-deoxy-1-methylaminosorbitolMixtures: UROGRAFIN %76 IV ENJEKSIYON VE INFUZYON ICIN COZELTI, 100 ML, UROGRAFIN %76 IV ENJEKSIYON VE INFUZYON ICIN COZELTI, 50 ML
  7. Drug

    Influenza B virus B/Phuket/3073/2013 BVR-1B antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB15788
    ApprovedInvestigationalWithdrawn

    Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. … Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals.

    Synonyms: Influenza B virus B/Phuket/3073/2013 BVR-1B antigen (formaldehyde inactivated)Mixtures: Afluria Tetra Injektionssuspension in einer Fertigspritze
  8. Drug

    Clostridium tetani

    go.drugbank.com/drugs/DB09876
    ApprovedInvestigational

    Mixtures: Boostrix Injektionssuspension in einer Fertigspritze, Boostrix Polio - Injektionssuspension in einer Fertigspritze
  9. Drug

    Influenza A virus A/California/7/2009 X-181 (H1N1) hemagglutinin antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB14404
    ApprovedWithdrawn

    Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. … Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals.

    Mixtures: FluVaccinol Subunit Tetra Injektionssuspension in einer FertigspritzeSynonyms: Influenza A virus A/California/7/2009 X-181 (H1N1) hemagglutinin antigen (formaldehyde inactivated)
  10. Pathway

    Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126504
    Drug action

    In addition to blocking conduction in nerve axons in the peripheral nervous system, lidocaine has important effects on the central nervous system and cardiovascular system. … In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others.

    Drugs: Lidocaine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2