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Mexiletine Action Pathway (New)
smpdb.ca/view/SMP0126263Drug actionThe decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. … Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Procainamide Action Pathway (New)
smpdb.ca/view/SMP0126265Drug actionPhenytoin slows the rate of rise in the pacemaker potential and shortens the plateau phase of atrial and ventricular myocytes as well as purkinje fibre cells as they have 'fast' action potential.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Moricizine Action Pathway
smpdb.ca/view/SMP0126950Drug actionThis results in a slowed atrioventricular nodal and His-Purkinje conduction, which decreases excitability conduction velocity, and automaticity.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Mestranol
go.drugbank.com/drugs/DB01357ApprovedWithdrawnThe 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
Mixtures: LUTORAL-E, Norinyl 1/50 28 TabCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesTolevamer
go.drugbank.com/drugs/DB01344ApprovedIt may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. … Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels.
Categories: Compounds used in a research, industrial, or household setting, Ion Exchange ResinsSynonyms: poly(styrene-4-sulfonic acid)Influenza A virus A/Texas/50/2012 X-223A (H3N2) hemagglutinin antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB14389ApprovedInactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3. … Inactivated virus cannot replicate, and therefore cannot cause disease from infection, even in immunocompromised individuals.
Mixtures: FluVaccinol Subunit Tetra Injektionssuspension in einer FertigspritzeSynonyms: Influenza A virus A/Texas/50/2012 X-223A (H3N2) hemagglutinin antigen (formaldehyde inactivated)Clostridium tetani
go.drugbank.com/drugs/DB09876ApprovedInvestigationalMixtures: Boostrix Injektionssuspension in einer Fertigspritze, Boostrix Polio - Injektionssuspension in einer FertigspritzeRivoceranib
go.drugbank.com/drugs/DB14765InvestigationalRivoceranib is under investigation in clinical trial NCT02726854 (Apatinib as Second-line Treatment of Advanced Pancreatic Cancer).
Categories: Heterocyclic Compounds, 1-RingLidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126504Drug actionIn addition to blocking conduction in nerve axons in the peripheral nervous system, lidocaine has important effects on the central nervous system and cardiovascular system. … In doing so, however, it can block or decrease muscle contractile, resulting in effects like vasodilation, hypotension, and irregular heart rate, among others.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2IDD-3
go.drugbank.com/drugs/DB05427ExperimentalIDD-3 is a therapeutic specific immunostimulant developed by IDM Pharma in partnership with sanofi-aventis. It consists of mature dendritic cells loaded with lysates from melanoma tumor cell lines. … It includes Dendritophages that are dendritic cells, a type of specialized immune cells derived from the patient's own white blood cells.
Synonyms: IDD-3