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GTP-binding protein Rheb
go.drugbank.com/bio_entities/BE0004594TargetHumansIn response to nutrients, growth factors or amino acids, specifically activates the protein kinase activity of MTOR, the catalytic component of the mTORC1 complex: acts by causing a conformational change … In response to starvation, RHEB is inactivated by the TSC-TBC complex, preventing activation of mTORC1 (PubMed:24529379, PubMed:33157014). Has low intrinsic GTPase activity (PubMed:15340059)
Synonyms: Ras homolog enriched in brainNaftifine
go.drugbank.com/drugs/DB00735ApprovedNaftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum
International brands: A MeiProducts: EXODERIL %1 KREM, 15 G, EXODERIL %1 KREM, 30 GProtein RecA
go.drugbank.com/bio_entities/BE0001257TargetDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Probably involved in base excision repair (PubMed:19303848). … Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded
Synonyms: Recombinase AProtein RecA
go.drugbank.com/bio_entities/BE0003084TargetShigella flexneriCan catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded
Synonyms: Recombinase ADegenerative Joint Disease of Hip
go.drugbank.com/conditions/DBCOND0110588Drugs: DiacereinSynonyms: O/A, Osteoarthritis in the Hip JointMonoamine oxidase
go.drugbank.com/bio_entities/BE0004909TargetEnzymeHumansof neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). … Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism
Polypeptides: Amine oxidase [flavin-containing] ASynonyms: MAO-A, Monoamine oxidase type AMeclizine
go.drugbank.com/drugs/DB00737ApprovedInvestigationalMeclizine is a histamine H1 antagonist with antiemetic and antivertigo properties. … [L6760] Commonly marketed under the brand name Antivert in the U.S., meclizine is available as oral tablets.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: Dramamine - N, Motion Sickness IITryptophan
go.drugbank.com/drugs/DB00150ApprovedInvestigationalNutraceuticalWithdrawnIt is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals. … An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants.
Mixtures: NUTRIPLUS LIPID SENZA ELETTROLITI, NUTRIPLUS LIPID SENZA ELETTROLITISynonyms: L-β-3-indolylalanine, (2S)-2-amino-3-(1H-indol-3-yl)propanoic acidAtracurium besylate
go.drugbank.com/drugs/DB00732ApprovedA non-depolarizing neuromuscular blocking agent with short duration of action. … Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents
Categories: Heterocyclic Compounds, 2-RingProducts: ATRACURIUM LABATEC IV SOLUTION FOR INJECTION 10MG/ML, ./5 มล. ชนิดฉีด)Glabellar Frown Lines (GL)
go.drugbank.com/conditions/DBCOND0081153Drugs: Botulinum toxin type ASynonyms: Glabellar Lines, Glabellar Frown Lines