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Delavirdine
go.drugbank.com/drugs/DB00705ApprovedInvestigationalWithdrawnA potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseSynonyms: (N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide), 2-(4-(5-methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamineVascular endothelial growth factor A, long form
go.drugbank.com/bio_entities/BE0000163TargetHumansParticipates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). … Involved in protecting cells from hypoxia-mediated cell death (By similarity)
Polypeptides: Vascular endothelial growth factor A, long formMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigationalThe intention of substitution of illicit opioids with the long-acting opioids used in OAT is to prevent withdrawal symptoms for 24-36 hours following dosing to ultimately reduce cravings and drug-seeking … [F4685,F4688,F4691,A185885,A185900,A185903] Due to its unique mechanism of action, methadone is particularly useful for the management of hard to treat pain syndromes such as neuropathic pain and cancer
Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersVaborbactam
go.drugbank.com/drugs/DB12107ApprovedInvestigationalIn August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the FDA for the treatment of adult patients with complicated urinary tract infections (cUTI). … Vabomere consists of vaborbactam and [Meropenem] for intravenous administration.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseGlecaprevir
go.drugbank.com/drugs/DB13879ApprovedInvestigationalAs of June 2025, the FDA approved an expanded indication for Mavyret, making it the first and only direct-acting antiviral therapy approved for the treatment of both acute and chronic HCV in patients aged … Mavyret is also indicated for HCV genotype 1-infected patients who have been previously treated with regimens either containing an NS5A inhibitor or an NS3/4A protease inhibitor, but not both [L940].
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseProthrombin
go.drugbank.com/drugs/DB11311ApprovedInvestigationalProthrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with
Mixtures: BERIPLEX P/N 500 POWDER FOR SOLUTION FOR INJECTION, OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IUSynonyms: Factor II, Factor II (prothrombin)Adagrasib
go.drugbank.com/drugs/DB15568ApprovedInvestigationalThe phase II of the same study showed that in patients with KRAS<sup>G12C</sup>-mutated non-small-cell lung cancer (NSCLC), adagrasib was efficient without new safety signals. … KRAS mutations are highly common in cancer and account for approximately 85% of all RAS family mutations.
Choline C 11
go.drugbank.com/drugs/DB09277ApprovedCholine C 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of phospholipids which are essential components of all cell membranes. … [A32041] It was developed by MCPRF and FDA first approved in September 2012.
Potassium guaiacolsulfonate
go.drugbank.com/drugs/DB13735ApprovedWithdrawnGuaiacolsulfonate is an aromatic sulfonic acid. Potassium guaiacolsulfonate salt is an expectorant that thins the mucus in the lungs and reduces chest congestion.
Categories: Potassium SaltReboxetine
go.drugbank.com/drugs/DB00234ApprovedInvestigationalWithdrawnIts mesylate (i.e. methanesulfonate) salt is sold under tradenames including Edronax, Norebox, Prolift, Solvex, Davedax or Vestra. … Reboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine.