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Mipomersen
go.drugbank.com/drugs/DB05528ApprovedMipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. … Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide.
Categories: Apolipoprotein B-100 Synthesis Inhibitor, Compounds used in a research, industrial, or household settingFruquintinib
go.drugbank.com/drugs/DB11679ApprovedInvestigationalFruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis. … The first approach can be exemplified by [bevacizumab], a VEGF-A trap antibody.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesDeserpidine
go.drugbank.com/drugs/DB01089ApprovedWithdrawnDeserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic beh...
Categories: Heterocyclic Compounds, 2-RingIbudilast
go.drugbank.com/drugs/DB05266InvestigationalIbudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume … (codes: AV-411 or MN-166), but is approved for use as an antiinflammatory in Japan.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSacubitril
go.drugbank.com/drugs/DB09292ApprovedInvestigationalIt was approved by the FDA after being given the status of priority review for on July 7, 2015. … BNP), and c-type natriuretic peptide (CNP).
Mixtures: ENTRESTO 50 MG, ENTRESTO 50 MGCategories: Heterocyclic Compounds, 1-RingFluorocholine F-18
go.drugbank.com/drugs/DB15887InvestigationalSalts: Fluorocholine chloride F-18Synonyms: Fluorocholine F-18Dipotassium phosphate
go.drugbank.com/drugs/DB09414ApprovedInvestigationalDipotassium phosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.
Mixtures: ISOLYTE-P PVC 250 ML(SETLI), ISOLYTE-P PVC 250 ML(SETSIZ)Categories: Compounds used in a research, industrial, or household settingEnasidenib
go.drugbank.com/drugs/DB13874ApprovedInvestigationalgene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. … First developed by Agios Pharmaceuticals and licensed to Celgene, enasidenib was approved by U.S. Food and Drug Administration on August 1, 2017.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-olOdevixibat
go.drugbank.com/drugs/DB16261ApprovedInvestigational[A236808] Odevixibat was granted FDA and Health Canada approval on 20 July 2021 and 13 November 2023 respectively.[L34793,L49535] … [L34803] Previous therapies for PFIC included a bile acid sequestrant such as [ursodeoxycholic acid].
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 2-RingEstradiol cypionate
go.drugbank.com/drugs/DB13954ApprovedVet approvedThe primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. … As a pro-drug of estradiol, estradiol cypionate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located
Mixtures: FEMELIN®, FEMELIN®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 Substrates