Deserpidine

DB01089ApprovedWithdrawnSmall moleculeCatecholamine-depleting Sympatholytic

Deserpidine is an alkaloid that has been used to manage hypertension. A medication that has been used to lower blood pressure.

Mechanism: Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.
Curator reviewed
Primary indication: For the treatment of hypertension.Curator reviewed
Formula / weight: C₃₂H₃₈N₂O₈ · 578.6527 g/mol (avg)
First approval: United States, 1961
Also known as: Canescine · Raunormine · Recanescine
Code names: A-11025

Resolves to

Compound

UNII9016E3VB47CAS131-01-1ChEMBLCHEMBL1200515ChEBI27478PubChem8550KEGGD08194

Clinical / RWD

RxNorm62174ATCC02AA05ATCC02LA03PharmGKBPA164742966

Structure

InChIKeyCVBMAZKKCSYWQR-WCGOZPBSSA-NSMILES[H][C@]12C[C@@H](OC(=O)C3=CC(OC)=C(OC)C(OC)=C3)[C@H](OC)[C@@H](C(=O)OC)[C@@]1([H])C[C@@]1([H])N(CCC3=C1NC1=CC=CC=C31)C2

Targets

Q05940SLC18A2P12821ACE

What you can answer from here — as of September 12, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

638Drug interactionsStructured to mechanism, not free text

3Marketed productsAcross 1 country and 2 labellers

2ATC codesIncluding every combination product, plus 11 drug categories

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with Deserpidine, and which of those have an active Phase 3 trial?

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