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Amoxicillin
go.drugbank.com/drugs/DB01060ApprovedInvestigationalVet approvedAmoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin. Amoxicillin was gr...
Synonyms: p-Hydroxyampicillin, α-amino-p-hydroxybenzylpenicillinMixtures: AMOXICILLINA E ACIDO CLAVULANICO P-CARE, AMOXICILLINA E ACIDO CLAVULANICO P-CAREMelatonin
go.drugbank.com/drugs/DB01065ApprovedInvestigationalNutraceuticalVet approvedMelatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesMequitazine
go.drugbank.com/drugs/DB01071InvestigationalMequitazine is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesPrimaquine
go.drugbank.com/drugs/DB01087ApprovedInvestigationalAn aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by tho...
Categories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein inhibitorsDimethyl sulfoxide
go.drugbank.com/drugs/DB01093ApprovedInvestigationalVet approvedA highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue dur...
Categories: Cytochrome P-450 CYP2C19 Inhibitors, Cytochrome P-450 CYP2D6 InhibitorsHesperetin
go.drugbank.com/drugs/DB01094InvestigationalHesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesPimozide
go.drugbank.com/drugs/DB01100ApprovedA diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknow...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesDiazoxide
go.drugbank.com/drugs/DB01119ApprovedInvestigationalDiazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels. It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsTolbutamide
go.drugbank.com/drugs/DB01124ApprovedTolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of...
Synonyms: 1-Butyl-3-(p-tolylsulfonyl)urea, 1-p-Toluenesulfonyl-3-butylureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C18 SubstratesDutasteride
go.drugbank.com/drugs/DB01126ApprovedInvestigationalDutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates