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Displaying results 211 - 220 of 10000 in total
  1. Drug

    Topiramate

    go.drugbank.com/drugs/DB00273
    ApprovedInvestigational

    [L10550] Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. … Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996.

    Products: Nu-topiramate, Nra-topiramate
  2. Drug

    Leflunomide

    go.drugbank.com/drugs/DB01097
    ApprovedInvestigational

    Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous.

    Synonyms: 4-ISOXAZOLECARBOXAMIDE, 5-METHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamideProducts: Nu-leflunomide, LEFLUNOMID 1A PHARMA 10MG
  3. Target

    Solute carrier family 13 member 2

    go.drugbank.com/bio_entities/BE0000447
    TransporterHumans

    Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10894787, PubMed:8967342, PubMed:9668069).

    Synonyms: Na(+)/dicarboxylate cotransporter 1
  4. Drug

    Budesonide

    go.drugbank.com/drugs/DB01222
    ApprovedInvestigational

    Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. … [L10598] It is also available in a combination product with [formoterol].[L10619]

    Products: AEROSIAL N, BUDES N 0.2MG DOS.AEROSOL
  5. Target

    Sodium/hydrogen exchanger 2

    go.drugbank.com/bio_entities/BE0020524
    TransporterHumans

    Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). … Major apical Na(+)/H(+) exchanger in the base of the colonic crypt.

    Synonyms: Na(+)/H(+) exchanger 2
  6. Target

    Sodium-dependent phosphate transport protein 2A

    go.drugbank.com/bio_entities/BE0008681
    TransporterHumans

    The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity) … Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:12324554, PubMed:20335586, PubMed:26047794, PubMed:8327470).

    Synonyms: Na(+)/Pi cotransporter 2A, Na(+)-dependent phosphate cotransporter 2A
  7. Drug

    Pomalidomide

    go.drugbank.com/drugs/DB08910
    ApprovedInvestigational

    Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexProducts: Nat-pomalidomide
  8. Drug

    Hydrochlorothiazide

    go.drugbank.com/drugs/DB00999
    ApprovedInvestigationalVet approved

    Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension. Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combinati...

    Mixtures: Nu-lisinopril/hctz, Nu-lisinopril/hctzProducts: Nu-hydro, HCT 1A PHARMA 25MG TABL
  9. Drug

    Terbinafine

    go.drugbank.com/drugs/DB00857
    ApprovedInvestigationalVet approved

    Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. … [A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall

    Synonyms: (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine, (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamineProducts: Nu-terbinafine, FILUT NX® SOLUCION
  10. Drug

    Glucosamine

    go.drugbank.com/drugs/DB01296
    Approved

    Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation. … Glucosamine is commonly used over the counter as a treatment for arthritic joint pain, although its acceptance as a medical therapy varies due to contradictory and findings with unclear clinical significance

    Products: Nn Bio-Glucosamine 500 Tablet, Nn Glucosamine vegetable capsule 500mg