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Tenofovir
go.drugbank.com/drugs/DB14126Investigational[A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog. … [A37693] The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially available since 2008 in the form of [tenofovir disoproxil] and [tenofovir alafenamide] in order
Arbaclofen
go.drugbank.com/drugs/DB08891InvestigationalIt has also been investigated as a treatment for spasticity due to multiple sclerosis and spinal cord injury. … Arbaclofen was investigated as a treatment for gastroesophageal reflux disease (GERD); however, with disappointing results.
Aducanumab
go.drugbank.com/drugs/DB12274ApprovedInvestigationalthe data [A235720] and aducanumab was granted accelerated FDA approval on 7 June 2021. … [A235668,A235720] Clinical trials showed a 23% relative difference between the experimental and placebo groups as determined by CDR; however, this is equivalent to an absolute difference of 0.4/18.
Fezolinetant
go.drugbank.com/drugs/DB15669ApprovedInvestigationaleffective treatments for VMS by relieving symptoms in as many as 95% of menopausal women. … [A259542] Fezolinetant, an NK3 receptor antagonist, was developed in response to this issue as well as more understanding of the role of NK3R in the hypothalamic-pituitary-gonadal (HPG) axis.
Lifileucel
go.drugbank.com/drugs/DB17107ApprovedInvestigationaltumour-derived autologous T cell immunotherapy composed of a suspension of tumour-derived T cells from the patient [L50171] which undergo isolation, ex vivo expansion, and activation[A263341] Lifileucel was
Gemeprost
go.drugbank.com/drugs/DB08964ApprovedWithdrawnIt is not FDA-approved but available in Japan marketed as Preglandin. … It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy [A19726].
Nitroprusside
go.drugbank.com/drugs/DB00325ApprovedInvestigationalNitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles).