Gemeprost

DB08964ApprovedWithdrawnSmall molecule

Gemeprost is a prostaglandin E1 analogue used for cervical dilation and, in combination with mifepristone, for pregnancy termination. Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion.

Chemical structure of Gemeprost
Mechanism
Curator reviewed · 1 reference
Primary indication
Indicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients in the second trimester of...Curator reviewed · 2 structured indications
Formula / weight
C23H38O5 · 394.552 g/mol (avg)
Code names
SC-37681

Resolves to

Compound
UNII45KZB1FOLSCAS64318-79-2ChEMBLCHEMBL1908315ChEBI135626PubChem5282237KEGGD02073
Clinical / RWD
RxNorm12449ATCG02AD03
Structure
InChIKeyKYBOHGVERHWSSV-VNIVIJDLSA-NSMILESCCCCC(C)(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(=O)OC
Targets
P43115PTGER3P43116PTGER2

What you can answer from here — as of August 01, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1Drug interactionStructured to mechanism, not free text
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11Clinical trialsPhase, status and sponsor resolved per trial
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2Structured indicationsCondition, population, route and combination as fields, not prose
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2ContraindicationsEach with its own population and attribute set
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2Marketed productsAcross 2 countries and 1 labeller
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1ATC codeIncluding every combination product, plus 17 drug categories
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8+ReferencesStructured and connected to the statements they support
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