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Artefenomel
go.drugbank.com/drugs/DB11809InvestigationalArtefenomel has been investigated for the treatment of Malaria.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsBaricitinib
go.drugbank.com/drugs/DB11817ApprovedInvestigationalBaricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthrit...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesPritelivir
go.drugbank.com/drugs/DB11844InvestigationalPritelivir has been used in trials studying the prevention of HSV-2 and Genital Herpes.
Categories: P-glycoprotein substratesRevefenacin
go.drugbank.com/drugs/DB11855ApprovedInvestigationalRevefenacin is a novel biphenyl carbamate tertiary amine agent that belongs to the family of the long-acting muscarinic antagonists (LAMA). The labile primary amide in the structure produces a "soft-drug" site that allows rapid systemic ...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesPenfluridol
go.drugbank.com/drugs/DB13791InvestigationalCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTestosterone undecanoate
go.drugbank.com/drugs/DB13946ApprovedInvestigationalTestosterone undecanoate is the ester prodrug of testosterone and has a mid-chain fatty acid at the carbon 17β position. It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone. T...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesStanolone acetate
go.drugbank.com/drugs/DB13951ExperimentalStanolone acetate is a synthetic androgen and anabolic steroid and a dihydrotestosterone ester that was never marketed.
Categories: P-glycoprotein substratesEstradiol acetate
go.drugbank.com/drugs/DB13952ApprovedVet approvedAs a pro-drug of estradiol, estradiol acetate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located in … exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol at the receptor
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A1 SubstratesEstradiol dienanthate
go.drugbank.com/drugs/DB13955ApprovedVet approvedWithdrawnAs a pro-drug of estradiol, estradiol benzoate therefore has the same downstream effects within the body through binding to the Estrogen Receptor (ER) including ERα and ERβ subtypes, which are located
Categories: Cytochrome P-450 CYP1A1 Substrates, P-glycoprotein substratesFish oil
go.drugbank.com/drugs/DB13961ApprovedInvestigationalNutraceuticalFish oil is a component of SMOFLIPID, which was FDA approved in July 2016. It is indicated in adults as a source of calories and essential fatty acids for parenteral nutrition when oral or enteral nutrition is not possible, insufficient,...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates