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Vatalanib
go.drugbank.com/drugs/DB04879InvestigationalVatalanib (PTK787/ZK-222584) is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. … Vatalanib is under investigation for the treatment of solid tumors.
Categories: Heterocyclic Compounds, 1-RingPepsin
go.drugbank.com/drugs/DB13198ApprovedWithdrawnPepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products [L2358]. … Stimulation of the pancreas and therefore enzymatic digestion of food is a tightly controlled and is a hormonally mediated process.
Mixtures: Debiline H, Glutamic Acid HCl Betaine HCl W PepsinCategories: Pepsin A, antagonists & inhibitorsTeduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalTeduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … The significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.
Categories: Compounds used in a research, industrial, or household setting, Glucagon-like Peptide-2 (GLP-2) AgonistsSynonyms: Glucagon-like peptide II (2-glycine) (human), Gly(2)-GLP-2Magnesium acetate
go.drugbank.com/drugs/DB13996ApprovedSynonyms: Mg(II) acetate, Acetic acid, magnesium salt (2:1)Mixtures: Plasma-lyte 56 5% Dextrose Inj, AMINOPLASMAL-5% E INFUSIONTechnetium Tc-99m exametazime
go.drugbank.com/drugs/DB09163ApprovedTechnetium Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases. … It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease.
Categories: Compounds used in a research, industrial, or household settingMethylphenidate
go.drugbank.com/drugs/DB00422ApprovedInvestigationalLong-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options … In contrast, low doses are found to selectively activate NE and DA neurotransmission within the prefrontal cortex which is an area of the brain thought to play a prominent role in ADHD pathophysiology,
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-RingSynonyms: methyl α-phenyl-α-(2-piperidyl)acetate, methyl α-phenyl-α-2-piperidinylacetateRanolazine Action Pathway
smpdb.ca/view/SMP0126279Drug actionMyocardial ischemia exerts effects on adenosine triphosphate flux, leading to a decrease in the energy available for contraction and relaxation of the heart muscle. … The clinical significance this inhibition in the treatment of angina symptoms is not yet confirmed. It has been shown to exert weak activity on L-type calcium channels.
Enzymes: Potassium voltage-gated channel subfamily E member 1, Potassium voltage-gated channel subfamily E member 2Etoperidone
go.drugbank.com/drugs/DB09194ApprovedWithdrawnEtoperidone is an atypical antidepressant introduced in Europe in 1977. … It is a phenylpiperazine-substituted triazole derivative with a composition that classifies it as an analog of tradozone and presents a similar pharmacological profile.
Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT2 Receptor AntagonistsColchicine
go.drugbank.com/drugs/DB01394ApprovedInvestigationalColchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus."[A183611] Its use was first approved by the FDA in 1961. … [L47591] It has also been investigated in other inflammatory and fibrotic conditions.[A183602]
Categories: Preparations With No Effect on Uric Acid Metabolism, P-glycoprotein inducersProducts: PMS-colchicine ER, L-CISINSamidorphan
go.drugbank.com/drugs/DB12543ApprovedInvestigational[A235623, A235638, L34359] Although antipsychotic-induced weight gain is incompletely understood, it is thought that the opioid system plays a key role in feeding and metabolism, such that opioid antagonism … , and a longer half-life, making it an attractive candidate for oral dosing.
Salts: Samidorphan L-malateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates