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Interferon alfa-2b
go.drugbank.com/drugs/DB00105ApprovedInvestigationalInterferon alpha 2b (human leukocyte clone hif-sn 206 protein moiety reduced). A type I interferon consisting of 165 amino acid residues with arginine in position 23. … This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent.
Mixtures: Rebetron Ready To Use Solution (albumin(human)free) (6000000 Iu/ml and 200mg Capsules), Intron ACategories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsAlmotriptan
go.drugbank.com/drugs/DB00918ApprovedAlmotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. … It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidineMesalazine
go.drugbank.com/drugs/DB00244ApprovedInvestigationalThroughout the late seventies and the eighties, important research initiatives developed stable mesalazine formulations like the eudragit-S coating of Asacol brand mesalazine and the Pentasa brand's encapsulation … the risk of colorectal cancer in conditions like ulcerative colitis is maintained.
Synonyms: 3-carboxy-4-hydroxyaniline, 5-ASAProducts: PENTASA®1 G GRANULOS DE LIBERACION PROLONGADA, PENTASA® GRANULOS DE LIBERACION PROLONGADA 2 GMeticillin
go.drugbank.com/drugs/DB01603ApprovedInvestigationalOne of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2,6-Dimethoxybenzamido)penicillanic acidDyclonine
go.drugbank.com/drugs/DB00645ApprovedInvestigationalDyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It may also be found in some Cepacol sore throat spray products.
Synonyms: 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone, 4-n-butoxy-β-(1-piperidyl)propiophenoneProducts: Sucrets MS WintergreenNialamide
go.drugbank.com/drugs/DB04820ApprovedWithdrawnWithdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.
Categories: Heterocyclic Compounds, 1-Ring, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: 1-(2-(Benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine, N-Isonicotinoyl-N'(beta-N-benzylcarboxamidoethyl)hydrazinePegvaliase
go.drugbank.com/drugs/DB12839ApprovedInvestigational/L to 3690 µmol/L [A33286]. … Phenylketonuria is a rare autosomal recessive disorder that is characterized by deficiency of the enzyme phenylalanine hydroxylase (PAH) [A33284] and affects about 1 in 10,000 to 15,000 people in the United
Desmopressin
go.drugbank.com/drugs/DB00035ApprovedInvestigationalIt was designed through two primary chemical modifications of the natural hormone: the deamination of 1-cysteine and the substitution of L-arginine with D-arginine at the 8th position [A31661, A275458] … It is considered a first-line therapy for central diabetes insipidus but is ineffective in patients with nephrogenic diabetes insipidus, where the kidneys are non-responsive to the hormone [A275458, L56105
Synonyms: 1 deamino 8 D argininevasopressin, 1-(3-mercaptopropionic acid)-8-D-arginine-vasopressinProducts: OCTOSTIM 30 MCG/2 ML IV/SC ENJEKSIYON IÇIN ÇÖZELTI IÇEREN AMPUL, 1 ADET, OCTOSTIM IV/SC ENJEKSİYONLUK ÇÖZELTİAmiloxate
go.drugbank.com/drugs/DB11207ApprovedAmiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m [F35]. … It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with an anti-inflammatory activity [A32916].
Mixtures: The History of Whoo Jin Hae Yoon SunSynonyms: 3-(4-Methoxyphenyl)-2-propenoic acid, 3-methylbutyl ester, Isoamyl p-methoxycinnamateClomipramine
go.drugbank.com/drugs/DB01242ApprovedInvestigationalVet approvedClomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. … Clomipramine is rapidly absorbed from the gastrointestinal tract and demethylated in the liver to its primary active metabolite, desmethylclomipramine.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine, 3-(3-chloro-5H-dibenzo[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine