Nialamide

DB04820ApprovedWithdrawnSmall molecule

Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.

Mechanism: Nialamide was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. It is chemically related to iproniazide, another MAOI derived from isonicotinic acid. //
Curator reviewed
Formula / weight: C₁₆H₁₈N₄O₂ · 298.3397 g/mol (avg)
Code names: Lopac-N-1392

Resolves to

Compound

UNIIT2Q0RYM725CAS51-12-7ChEMBLCHEMBL1256841ChEBI94510PubChem4472

Clinical / RWD

RxNorm7394ATCN06AF02

Structure

InChIKeyNOIIUHRQUVNIDD-UHFFFAOYSA-NSMILESO=C(CCNNC(=O)C1=CC=NC=C1)NCC1=CC=CC=C1

Targets

P27338MAOBP21397MAOAP21964COMT

What you can answer from here — as of June 15, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,664Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 16 drug categories

11+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nialamide, and which of those have an active Phase 3 trial?

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