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Mirdametinib
go.drugbank.com/drugs/DB07101ApprovedInvestigationalMirdametinib is a mitogen-activated protein kinase (MAP2K, MEK, MAPKK) inhibitor. On February 11, 2025, mirdametinib was approved by the FDA for the treatment of neurofibromatosis type 1 (NF1). … [A265065] Mirdametinib selectively and potently inhibits the MEK1/2 enzymes.[A265065]
Categories: P-glycoprotein substratesSynonyms: (-)-N-(((R)-2,3-DIHYDROXYPROPYL)OXY)-3,4-DIFLUORO-2-((2-FLUORO-4-IODOPHENYL)AMINO)BENZAMIDE, N-(((R)-2,3-DIHYDROXYPROPYL)OXY)-3,4-DIFLUORO-2-((2-FLUORO-4-IODOPHENYL)AMINO)BENZAMIDEGuaiacol
go.drugbank.com/drugs/DB11359ApprovedGuaiacol is an agent thought to have disinfectant properties and used as an expectorant. Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin. … Guaiacol is also present in wood smoke, as a product of pyrolysis of lignin. Guaiacol has been found in the urine of patients with neuroblastoma and pheochromocytoma.
Mixtures: NOKTOS ® ADULTOS JARABE.Synonyms: 1-hydroxy-2-methoxybenzene, 2-methoxyl-4-vinylphenolAmifloxacin
go.drugbank.com/drugs/DB20048ExperimentalAmifloxacin is a small molecule drug. The usage of the INN stem '-oxacin' in the name indicates that Amifloxacin is a nalidixic acid derivative antibacterial. … Amifloxacin has a monoisotopic molecular weight of 334.14 Da.
Categories: Topoisomerase II Inhibitors, 4-QuinolonesBrentuximab vedotin
go.drugbank.com/drugs/DB08870ApprovedInvestigationalBrentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). … [L1737] Lymphoma is a malignancy that begins in the lymphatic system, which helps to combat infection and disease. Lymphoma may begin anywhere in the body and can spread to nearby lymph nodes.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: ADCETRIS®, ADCETRIS 50 MG IV INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇIN TOZ IÇEREN FLAKON ,FLAKON, 1 ADETHuman cytomegalovirus immune globulin
go.drugbank.com/drugs/DB13886ApprovedInvestigationalAs a consequence, CMV disease is restricted to the immunocompromised or immunologically immature host, in which it can lead the devastating result of transplant rejection [A32498], [L2229]. … Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human population, leading to infections which are followed by life-long dormancy in the host with occasional reactivations and recurrent
Categories: Immunoglobulin G, Human Immunoglobulin GProducts: MEGALOTECT CP SOLUTION FOR INFUSION 100 U/MLRozanolixizumab
go.drugbank.com/drugs/DB14919ApprovedInvestigationalRozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). … [A260192] As a result, the main clinical manifestation of myasthenia gravis is easily fatigable or persistent muscle weakness.
Products: Rystiggo 280 mg/2 ml Enjeksiyonluk Çözelti, 1 adetThonzylamine
go.drugbank.com/drugs/DB11235ApprovedThonzylamine is an antihistamine and anticholinergic drug. … It is available as combination products with [DB04837] or [DB00388] for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.
Categories: Heterocyclic Compounds, 1-RingBrexpiprazole
go.drugbank.com/drugs/DB09128ApprovedInvestigationalBrexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). … It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors.
Categories: MATE 2 Inhibitors, Cytochrome P-450 SubstratesProducts: REXULTI (BREXPIPRAZOLE) TABLETS 1 MG, REXULTI (BREXPIPRAZOLE) TABLETS 2 MGMiltefosine
go.drugbank.com/drugs/DB09031ApprovedInvestigationalMiltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid drug that was originally developed in the 1980s as an anti-cancer agent. … It is currently the only recognized oral agent used to treat visceral, cutaneous, and mucosal forms of leishmaniasis, a neglected tropical disease.
Synonyms: hexadecyl 2-(trimethylazaniumyl)ethyl phosphateCategories: P-glycoprotein substratesBulevirtide
go.drugbank.com/drugs/DB15248ApprovedInvestigational[A226305] Bulevirtide, also known as Hepcludex, is a first-in-class entry inhibitor for the treatment of chronic Hepatitis D infection developed by MYR Pharmaceuticals, now part of Gilead. … Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality.
International brands: Myrcludex B