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Lomustine
go.drugbank.com/drugs/DB01206ApprovedInvestigationalAn alkylating agent of value against both hematologic malignancies and solid tumors.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 CYP3A InhibitorsLevobunolol
go.drugbank.com/drugs/DB01210ApprovedA nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesHalofantrine
go.drugbank.com/drugs/DB01218ApprovedWithdrawnHalofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in th...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 SubstratesRifaximin
go.drugbank.com/drugs/DB01220ApprovedInvestigationalRifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple in...
Categories: Cytochrome P-450 CYP2C19 Inducers, Cytochrome P-450 SubstratesAripiprazole
go.drugbank.com/drugs/DB01238ApprovedInvestigationalAripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation ...
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsClomipramine
go.drugbank.com/drugs/DB01242ApprovedInvestigationalVet approvedClomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the c...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesDocetaxel
go.drugbank.com/drugs/DB01248ApprovedInvestigationalDocetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer. Docetaxel is a complex diterpenoid molecule a...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesRetapamulin
go.drugbank.com/drugs/DB01256ApprovedRetapamulin, marketed by GlaxoSmithKline as the ointment Altabax, is an antibiotic for skin infections like impetigo. It was approved by the FDA in April 2007.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDesonide
go.drugbank.com/drugs/DB01260ApprovedInvestigationalA nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 SubstratesDecitabine
go.drugbank.com/drugs/DB01262ApprovedInvestigationalMyelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic neoplasms with variable underlying etiology and presentation, including neutropenia and thrombocytopenia. Further mutations leading to increased proliferation of ...
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