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Trihexyphenidyl
go.drugbank.com/drugs/DB00376ApprovedInvestigational[A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects. … [L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.
Categories: Heterocyclic Compounds, 1-RingProducts: POZHEXOL 5, ACA (5 mg.)Drometrizole trisiloxane
go.drugbank.com/drugs/DB11585ApprovedDespite being used elsewhere in the world with relatively few reports of adverse reactions, the FDA continues to cite that the existing scientific record is not sufficient to establish the compound as … The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia
Mixtures: Anthelios XL Melt-IN Cream, Garnier Ombrelle SPF 30 UVA UVB Kids Wet N Protect Sunscreen Protection Even on Wet Skin Hypoallergenic Water/sweat resistant 80 minutes Quick AbsorptionCategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingVorinostat
go.drugbank.com/drugs/DB02546ApprovedInvestigationalIt is the first in a new class of agents known as histone deacetylase inhibitors. … A recent study suggested that vorinostat also possesses some activity against recurrent glioblastoma multiforme, resulting in a median overall survival of 5.7 months (compared to 4 - 4.4 months in earlier
Products: ZOLINZA®VORINOSTAT 100 MG CAPSULASSertaconazole
go.drugbank.com/drugs/DB01153ApprovedSertaconazole nitrate is an antifungal medication of the imidazole class. It is available in topical formulations for the treatment of skin infections such as athlete's foot.
Categories: combinations of imidazole derivatives, Heterocyclic Compounds, 1-RingProducts: Konzert Cream 2%w/w, ZALAIN® 2% CREMADactylis glomerata pollen
go.drugbank.com/drugs/DB10379ApprovedDactylis glomerata pollen is the pollen of the Dactylis glomerata plant. Dactylis glomerata pollen is mainly used in allergenic testing.
Mixtures: SLITone ULTRA D. glomerata/ L. perenne/ P. pratense/ P. pratensis/ A. odoratum, ORALAIR 100 IR + 300 IR SublingualtablettenLamivudine
go.drugbank.com/drugs/DB00709ApprovedInvestigationalA reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. … It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Synonyms: beta-L-2',3'-Dideoxy-3'-thiacytidine, beta-L-3'-Thia-2',3'-dideoxycytidineMixtures: ABACAVIR E LAMIVUDINA DOC GENERICI, ZOVILAM PED DT®Vinflunine
go.drugbank.com/drugs/DB11641ApprovedInvestigationalIn 2009, vinflunine was approved by the European Medicines Agency (EMA) as a second-line therapy of metastatic and advanced urothelial cancer after failure of platinum-based treatment [A32626]. … Vinflunine is a third-generation member of the vinca alkaloid family with anti-tumour actions. It was first described in 1998 at the Pierre Fabre research center in France.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: 20',20'-difluoro-3',4'-dihydrovinorelbine, 4'-deoxy-20',20'-difluoro-5'-norvincaleukoblastineEculizumab
go.drugbank.com/drugs/DB01257ApprovedInvestigational[L6919,A2245,A2246] Eculizumab was granted FDA approval on 16 March 2007. … [L6919] In Q1 2023, the EMA's Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion of two formulations of eculizumab indicated for the treatment of paroxysmal nocturnal hemoglobinuria
Products: SOLIRIS ® 300 MGSOLUCION PARA INFUSIÓN INTRAVENOSA, ELIZARIA® 10MG/ML SOLUCIÓN CONCENTRADA PARA INFUSIÓNLeniolisib
go.drugbank.com/drugs/DB16217ApprovedInvestigationalThe FDA approved leniolisib on March 24, 2023, making it the first treatment for activated phosphoinositide 3-kinase delta syndrome (APDS). … [L45758] APDS is a primary immunodeficiency caused by mutations in genes encoding the PI3Kδ, thereby increasing the activity of PI3Kδ, causing immune dysfunction, and elevating susceptibility to infections
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesCupric Chloride
go.drugbank.com/drugs/DB09131ApprovedCupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Mixtures: Tracel Injektionslösung in einer Fertigspritze, ADDAMEL NSynonyms: copper(II) chloride, Copper(2+) chloride