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Finerenone
go.drugbank.com/drugs/DB16165ApprovedInvestigational[A236544] Eplerenone is more selective and has longer lasting effects. … [A236544] So far, finerenone is the only nonsteroidal mineralocorticoid receptor antagonist to be FDA approved.
Anti-CD7 CAR-T
go.drugbank.com/drugs/DB23322InvestigationalCD7 CAR-T is a biologic drug. CD7 CAR-T is under investigation in clinical trial NCT07117305 (CD7 CAR-T Combined With Autologous Hematopoietic Stem Cell Transplantation).
Fluciclovine (18F)
go.drugbank.com/drugs/DB13146ApprovedInvestigationalFluciclovine is a [18F]-tagged synthetic analog of the amino acid L-leucine. It presents excellent diagnostic properties to be used in positron emission tomography (PET) imaging.
Trypsin
go.drugbank.com/drugs/DB11237ApprovedInvestigationalVet approvedTrypsin contains a nucleophilic residue Ser in the enzyme active site which attacks the carbonyl moiety of the substrate peptide bond to form an acyl-enzyme intermediate [A27241]. … Therapeutic forms of trypsin is obtained from purified extracts of porcine or bovine pancreas and is intended to aid in digestion when administered orally.
Mixtures: Trypsin ComplexBitolterol
go.drugbank.com/drugs/DB00901ApprovedWithdrawnIt is a beta-2-adrenergic receptor agonist. Bitolterol was withdrawn from the market by Elan Pharmaceuticals in 2001.
Hexachlorophene
go.drugbank.com/drugs/DB00756ApprovedWithdrawnIt is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Deferiprone
go.drugbank.com/drugs/DB08826ApprovedInvestigationalAs a result, erythropoiesis, the production of new red blood cells, is impaired. FDA approved on October 14, 2011. … Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs.
CD68-ET3-LV
go.drugbank.com/drugs/DB32864InvestigationalCD68-ET3-LV is an autologous gene therapy consisting of CD34+ hematopoietic stem and progenitor cells transduced ex-vivo with the CD68-ET3-LV lentiviral vector.
Zavegepant
go.drugbank.com/drugs/DB15688ApprovedInvestigationalSince they inhibit these mechanisms and desensitize neuronal circuits, the use of CGRP receptor antagonists is beneficial in the treatment of migraine. … [L45505] CGRP is released from sensory nerves and acts as a strong vasodilator, and thanks to these properties, it is involved in pain pathways.