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Zaleplon
go.drugbank.com/drugs/DB00962ApprovedIllicitZaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCinacalcet
go.drugbank.com/drugs/DB01012ApprovedInvestigationalCinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesTopotecan
go.drugbank.com/drugs/DB01030ApprovedInvestigationalAn antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InhibitorsProcainamide
go.drugbank.com/drugs/DB01035ApprovedA derivative of procaine with less CNS action.
Synonyms: p-Aminobenzoic diethylaminoethylamide, p-Amino-N-(2-diethylaminoethyl)benzamideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesBenzylpenicillin
go.drugbank.com/drugs/DB01053ApprovedInvestigationalVet approvedBenzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorptio...
Synonyms: PGMixtures: Bicillin A-P Injection Pws, Bicillin A-P Injection PwsAmoxicillin
go.drugbank.com/drugs/DB01060ApprovedInvestigationalVet approvedAmoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin. Amoxicillin was gr...
Mixtures: AMOXICILLINA E ACIDO CLAVULANICO P-CARE, AMOXICILLINA E ACIDO CLAVULANICO P-CARECategories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 Enzyme InhibitorsPrimaquine
go.drugbank.com/drugs/DB01087ApprovedInvestigationalAn aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by tho...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTolbutamide
go.drugbank.com/drugs/DB01124ApprovedTolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of...
Synonyms: 1-Butyl-3-(p-tolylsulfonyl)urea, 1-p-Toluenesulfonyl-3-butylureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C18 SubstratesNefazodone
go.drugbank.com/drugs/DB01149ApprovedWithdrawnNefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic i...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsHalothane
go.drugbank.com/drugs/DB01159ApprovedVet approvedWithdrawnA nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce suffi...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates