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Amylocaine
go.drugbank.com/drugs/DB09088ApprovedWithdrawnAlthough amylocaine could be administered topically or injected, it was most widely used for spinal anesthesia [L1882]. … Elsewhere in English speaking countries it was referred to as Stovaine, given the meaning of the French word 'fourneau' as 'stove' in English [L1882].
Phenyl salicylate
go.drugbank.com/drugs/DB11071ApprovedIt is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. … It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in [DB00945] ).
Opicapone
go.drugbank.com/drugs/DB11632ApprovedInvestigational[L13772] It is marketed under the brand name Ongentys as once-daily oral capsules.
Idecabtagene vicleucel
go.drugbank.com/drugs/DB16665ApprovedInvestigational[A232563] These cancerous cells generally express the B-cell maturation antigen, while it is rarely expressed on non-cancerous cells.
Exenatide
go.drugbank.com/drugs/DB01276ApprovedInvestigationalIt activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control[L42690]. … It is available as immediate- and extended-release formulations.[L42685,L42690] Bydureon, the brand name product of extended-release exenatide in an injectable suspension, was discontinued in 2021.
Lifitegrast
go.drugbank.com/drugs/DB11611ApprovedInvestigationalIt is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process. … It has shown to protect the corneal surface and alleviate the symptoms of dry eye syndrome with fast onset of action and well tolerated profile in both local and systemic setting [A18805].
Larotrectinib
go.drugbank.com/drugs/DB14723ApprovedInvestigationalIt was notable for being the second tissue-agnostic chemotherapy ever approved by the FDA.[L4847]. On April 10, 2025, the FDA granted full drug approval.[L52805]
Carprofen
go.drugbank.com/drugs/DB00821ApprovedVet approvedWithdrawnIt is no longer marketed for human usage, after being withdrawn on commercial grounds. … It was generally well tolerated, with the majority of adverse effects being mild, such as gastro-intestinal pain and nausea, similar to those recorded with aspirin and other non-steroidal anti-inflammatory
Medifoxamine
go.drugbank.com/drugs/DB13219ApprovedMedifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases of hepatotoxicity