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Displaying results 2341 - 2350 of 10000 in total
  1. Drug

    Ondansetron

    go.drugbank.com/drugs/DB00904
    ApprovedInvestigationalWithdrawn

    [L5221] The FDA withdrew its approval for the use of all intravenous drug products containing more than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation. … A competitive serotonin type 3 receptor antagonist.

    Categories: Antiemetics and Antinauseants, Serotonin 5-HT3 Receptor AntagonistsProducts: ONZYD 4 MG AGIZDA DAGILAN 10 TABLET, ONZYD 8 MG AGIZDA DAGILAN 10 TABLET
  2. Drug

    Ivermectin

    go.drugbank.com/drugs/DB00602
    ApprovedInvestigationalVet approved

    [L31453] Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1a</sub>) and 10% 5-O-demethyl-25-de … (1-methylpropyl)-22,23-dihydro­-25-(1-methylethyl)avermectin A<sub>1a</sub> (22,23-dihydroavermectin B<sub>1b</sub>).

    Mixtures: Ivermectin 1% / Metronidazole 1%, Ivermectin 1% / Metronidazole 1% / Niacinamide 4%Categories: Scabicides and Pediculicides, Antiparasitic Products, Insecticides and Repellents
  3. Drug

    Hepatitis B immune globulin

    go.drugbank.com/drugs/DB05276
    ApprovedInvestigational

    According to the Centers for Disease Control and Prevention (CDC), the hepatitis B vaccine was the first anti-cancer vaccine. … During the process, viruses are deactivated, and in the final steps, solvents used in the preparation are removed. The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus.

    Categories: hepatitis B immunoglobulin, Amino Acids, Peptides, and ProteinsSynonyms: Hepatitis B immune globulin, Hepatitis B immune globulin human
  4. Drug

    Pertuzumab

    go.drugbank.com/drugs/DB06366
    ApprovedInvestigational

    Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant therapy in the treatment of HER2-positive breast cancers at high risk of recurrence. … It consists of two heavy chains and two lights chains that have 448 and 214 residues respectively.

    Mixtures: PHESGO® 1200 MG/600 MG, PHESGO® 1200 MG/600 MGCategories: Receptor, ErbB-2, antagonists & inhibitors, HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
  5. Drug

    IMT-288

    go.drugbank.com/drugs/DB19068
    Investigational

    IMT-288 is under investigation in clinical trial NCT01730638 (Immunotep for Patients With Medullary Thyroid Carcinoma.).

    Synonyms: (4R)-5-(((1R)-1-CARBAMOYL-5-((2-((4-(2-(1H-IMIDAZOL-5-YL)ETHYLAMINO)-4-OXO-BUTANOYL)AMINO)ACETYL)AMINO)PENTYL)AMINO)-4-(((2R)-2-(((2R)-3-(4-HYDROXYPHENYL)-2-((2-(4,7,10-TRIS(CARBOXYMETHYL)-1,4,7,10-TETRAZACYCLODODEC, -1-YL)ACETYL)AMINO)PROPANOYL)AMINO)-6-(Categories: Amino Acids, Peptides, and Proteins
  6. Drug

    Quinapril

    go.drugbank.com/drugs/DB00881
    ApprovedInvestigational

    [A184844] Quinapril was granted FDA approval on 19 November 1991.[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423] … [L8420,L8423] It is used to treat hypertension and heart failure.

    Mixtures: ACCUZIDE FORT 20 MG/25 MG FILM KAPLI TABLET, 30 ADET, ACCUZIDE 20 MG/12.5 MG FILM TABLET, 30 ADETCategories: Heterocyclic Compounds, 2-Ring, ACE Inhibitors and Diuretics
  7. Drug

    Zolpidem

    go.drugbank.com/drugs/DB00425
    ApprovedInvestigational

    Research also shows that zolpidem is rapid and effective in restoring brain function for patients in a vegetative state following brain injury. … Its tolerability profile is favorable when administered according to the manufacturer’s instructions, with a low risk of drug withdrawal, drug dependence, and drug tolerance [A175426].

    Mixtures: Gabazolpidem-5, Sentrazolpidem PM-5Categories: Heterocyclic Compounds, 1-Ring, Hypnotics and Sedatives
  8. Drug

    Methylphenidate

    go.drugbank.com/drugs/DB00422
    ApprovedInvestigational

    Concerta also provides a sustained 10-12 hour effect, allowing for once-daily dosing. … The MLRTM release system allows for a sustained effect for 10-12 hours, allowing for once-daily dosing that covers the major times that ADHD impairment might occur (such as school, homework periods, during

    Mixtures: MEDIKINET MR, MEDIKINET MRCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-Ring
  9. Drug

    Lidocaine

    go.drugbank.com/drugs/DB00281
    ApprovedInvestigationalVet approved

    Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication [T583]. … As a result, lidocaine is also considered a class Ib anti-arrhythmic agent [L5930, L5948, F4468].

    Synonyms: 2-(Diethylamino)-2',6'-acetoxylidide, 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamideInternational brands: Lidoject-1, L-Caine
  10. Drug

    Verapamil

    go.drugbank.com/drugs/DB00661
    ApprovedInvestigational

    [L8791] Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold … Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced

    Mixtures: VERACOMB MR 180/2 MG KAPSÜL, 28 ADET, VERAPIN 180 MG/2 MG FILM KAPLI TABLET, 28 ADETCategories: MATE 1 Inhibitors, Adrenergic alpha-1 Receptor Antagonists