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Displaying results 2381 - 2390 of 8696 in total
  1. Target

    Neuronal acetylcholine receptor subunit alpha-9

    go.drugbank.com/bio_entities/BE0002343
    TargetHumans

    This may protect against acoustic trauma (By similarity). May also regulate keratinocyte adhesion (PubMed:11021840, PubMed:11752216, PubMed:25282151) … The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151)

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-9Synonyms: Nicotinic acetylcholine receptor subunit alpha-9
  2. Target

    Interleukin-13 receptor subunit alpha-2

    go.drugbank.com/bio_entities/BE0002421
    TargetHumans

    Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:11861389, PubMed:17030238). … Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1 (PubMed:16327802)

    Polypeptides: Interleukin-13 receptor subunit alpha-2Synonyms: IL-13 receptor subunit alpha-2
  3. Target

    G protein-coupled estrogen receptor 1

    go.drugbank.com/bio_entities/BE0003446
    TargetHumans

    Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). … G protein-coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways.

    Polypeptides: G protein-coupled estrogen receptor 1Synonyms: Chemoattractant receptor-like 2, IL8-related receptor DRY12
  4. Target

    Low affinity immunoglobulin epsilon Fc receptor

    go.drugbank.com/bio_entities/BE0003465
    TargetHumans

    Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells.

    Polypeptides: Low affinity immunoglobulin epsilon Fc receptorSynonyms: Lymphocyte IgE receptor
  5. Target

    Neuronal acetylcholine receptor subunit alpha-5

    go.drugbank.com/bio_entities/BE0003586
    TargetHumans

    Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2 (PubMed:8663494). Plays a role in nicotine addiction (PubMed:20881005)

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-5Function: acetylcholine receptor activity
  6. Target

    Gamma-aminobutyric acid receptor subunit pi

    go.drugbank.com/bio_entities/BE0003596
    TargetHumans

    Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a c...

    Polypeptides: Gamma-aminobutyric acid receptor subunit piSynonyms: GABA(A) receptor subunit pi
  7. Target

    T cell receptor alpha chain constant

    go.drugbank.com/bio_entities/BE0003778
    TargetHumans

    Constant region of T cell receptor (TR) alpha chain (PubMed:24600447).

    Polypeptides: T cell receptor alpha chain constant
  8. Target

    Hepatitis B virus receptor binding protein

    go.drugbank.com/bio_entities/BE0004339
    TargetHumans

    Polypeptides: Hepatitis B virus receptor binding protein
  9. Target

    Non-receptor tyrosine-protein kinase TNK1

    go.drugbank.com/bio_entities/BE0009400
    TargetHumans

    May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system.

    Polypeptides: Non-receptor tyrosine-protein kinase TNK1
  10. Target

    Muscle, skeletal receptor tyrosine-protein kinase

    go.drugbank.com/bio_entities/BE0009491
    TargetHumans

    May positively regulate Rho family GTPases through FNTA. … Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362

    Polypeptides: Muscle, skeletal receptor tyrosine-protein kinaseSynonyms: Muscle-specific kinase receptor, Muscle-specific tyrosine-protein kinase receptor