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Displaying results 231 - 240 of 10000 in total
  1. Target

    Keratin, type I cytoskeletal 16

    go.drugbank.com/bio_entities/BE0009086
    TargetHumans

    Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with type II keratins KRT6A and KRT6B, assembling into keratin intermediate filament networks that contribute to cytoskeletal resilience of ...

    Polypeptides: Keratin, type I cytoskeletal 16
  2. Drug

    Doxepin

    go.drugbank.com/drugs/DB01142
    ApprovedInvestigational

    [T83] In a strict sense, doxepin is not a tricyclic antidepressant but it is commonly associated with the class since it shares a lot of properties with members of the drug family including [amitriptyline … [T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture.

    Categories: Non-Selective Monoamine Reuptake Inhibitors, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: PURDOX %5 KREM, 30 G, EXPAN® 50 MG
  3. Drug

    Bromelains

    go.drugbank.com/drugs/DB13281
    ApprovedInvestigational

    It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins [A27197] and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. … It is considered as a safe food supplement.

    Mixtures: Alka-pan Tablets, BIOGROW® VITEProducts: Rocky Mountain Bromelain Cap 500mg, Bromelain Pineapple Enzyme 50 Mg Nu Life
  4. Drug

    Iopromide

    go.drugbank.com/drugs/DB09156
    Approved

    [A260751] Approved by the FDA in 1995 and Health Canada in 1994 under the brand name ULTRAVIST, iopromide is used in radiological diagnosis, including, but not limited to, intra-arterial digital subtraction … [A225366] Although iopromide can cause several serious adverse effects, including cardiac events, thromboembolism, hypersensitivity reaction, and even death if administered intrathecally inadvertently,

    Synonyms: N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamideCategories: Compounds used in a research, industrial, or household setting, X-Ray Contrast Activity
  5. Drug

    Benzethonium

    go.drugbank.com/drugs/DB11125
    Approved

    There is evidence that benzethonium acts as a spermatocide but may cause vaginal irritation [A32304]. … It is shown to be effective in mediating its antimicrobial action against bacteria, fungi, mold and viruses.

    Mixtures: Tough Guy Hand Sanitizer Wipes Tough GuyProducts: Lysol No Touch, Ino-F-san Instant Hand Sanitizer
  6. Drug

    Nifedipine

    go.drugbank.com/drugs/DB01115
    ApprovedInvestigational

    Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine]. … [A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.

    Synonyms: 4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsäuredimethylesterCategories: P-glycoprotein inducers, P-glycoprotein inhibitors
  7. Drug

    Bisacodyl

    go.drugbank.com/drugs/DB09020
    ApprovedInvestigational

    [A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956[L33045] but has been used as a laxative since 1952.[A233300] … [A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).

    Synonyms: Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)Mixtures: BEKUNIS 3 MG/5 MG KAPLI TABLET, 30 ADET, Dyrax-Q Tab
  8. Target

    Ornithine carbamoyltransferase subunit I

    go.drugbank.com/bio_entities/BE0001875
    TargetEscherichia coli (strain K12)

    Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which is a substrate for argininosuccinate synthetase, the enzyme involved in the f...

    Polypeptides: Ornithine carbamoyltransferase subunit ISynonyms: Ornithine carbamoyltransferase chain I
  9. Target

    Troponin I, cardiac muscle

    go.drugbank.com/bio_entities/BE0000656
    TargetHumans

    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity

    Polypeptides: Troponin I, cardiac muscleSynonyms: Cardiac troponin I
  10. Target

    DNA topoisomerase I, mitochondrial

    go.drugbank.com/bio_entities/BE0000091
    TargetHumans

    Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a t...

    Polypeptides: DNA topoisomerase I, mitochondrial