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Etoposide
go.drugbank.com/drugs/DB00773ApprovedInvestigationalAccumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. … Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding.
Categories: Topoisomerase II InhibitorsProducts: INJECTION ETOPOSIDE CS 100MG IN 5ML, Vepesid Inj 20mg/mlMepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalThe pathogenesis of eosinophilia is complex, but IL-5 is recognized as a key cytokine involved in the differentiation, recruitment, activation, and prolonged survival of eosinophils in peripheral tissue … Activated eosinophils further stimulate an inflammatory response and also induce tissue lesions and promote fibrosis, all of which contribute to the multifactorial symptomatology of hypereosinophilic diseases
Products: NUCALA SOLUTION FOR INJECTION IN PRE-FILLED PEN 100MG/ML, NUCALA SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 100MG/MLPaclitaxel
go.drugbank.com/drugs/DB01229ApprovedInvestigationalVet approvedUsed as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel … It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane.
Synonyms: 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserineProducts: PLACLITAX®INY, SINDAXEL 300 MG/50 ML IV INF. KONSANTRE COZ. ICEREN FLAKON, 1 ADETAsparaginase Escherichia coli
go.drugbank.com/drugs/DB00023ApprovedInvestigationalAsparaginase from _E. coli_ has clinically shown to exhibit antitumor actions in models of leukaemias [A31996, A31997]. … L-asparaginase of _E. coli_ is marketed under several different trade names, including Elspar, for the treatment of acute lymphoblastic leukemia (ALL) as part of a multi-agent chemotherapeutic regimen.
Synonyms: Asparaginase IIProducts: LEUNASE INJ., LEUNASE FOR INJECTION 10,000 iu/vialUrokinase
go.drugbank.com/drugs/DB00013ApprovedInvestigationalWithdrawnUrokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. … [A191943] Urokinase was granted FDA approval on 16 January 1978.[L12138]
Products: UROKINASE-GREEN CROSS INJ. 60,000 iu/vial, UROKINASE KGCC INJ. 250000 IU FLAKON, 1 ADETIncrease in Intracranial Pressure (ICP)
go.drugbank.com/conditions/DBCOND0113421Synonyms: Increase in Intracranial Pressure (ICP)Leydig Cell Failure in Adult
go.drugbank.com/conditions/DBCOND0081825Drugs: MesteroloneSynonyms: Leydig Cell Failure in Adult, Leydig cell failure in adult (disorder)Burning sensation in the mouth
go.drugbank.com/conditions/DBCOND0102063Drugs: Benzoic acidSynonyms: Discomfort in mouth, Burning sensation in the mouthDeficiencies in enzymes of the urea cycle
go.drugbank.com/conditions/DBCOND0023710Drugs: Phenylbutyric acidSynonyms: Deficiencies in enzymes of the urea cycleOxytocin
go.drugbank.com/drugs/DB00107ApprovedInvestigationalVet approvedDale first identified oxytocin and its uterine contractile properties in 1906. … [A229108,A229113] It is estimated that labor induction with oxytocin is used in almost 10% of deliveries globally.
Products: Oxyla 10 IU/mL Injection, Oxytocin Inj 10unit/ml USP