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Cyproheptadine
go.drugbank.com/drugs/DB00434ApprovedInvestigational[L32474] It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation[L32519] and its off-label use in the treatment of serotonin syndrome. … Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors.
Products: PRAKTEN 2 MG/5 ML ŞURUP, 240 ML, PRAKTEN SURUP, 240 MLTrimethadione
go.drugbank.com/drugs/DB00347ApprovedWithdrawnAn anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)
Vibrio cholerae CVD 103-HgR strain live antigen
go.drugbank.com/drugs/DB14443ApprovedInvestigational[A244494] Vaxchora was later approved by the European Commission in April 2020.[L39729] It is indicated for individuals aged two years and older.[L12801] … prevention to become available in the U.S.
Perfluorohexyloctane
go.drugbank.com/drugs/DB17823ApprovedInvestigationalPerfluorohexyloctane is a semifluorinated alkane that contains six perfluorinated carbon atoms and eight hydrogenated carbon atoms.[L46491] It is an inert, slightly amphiphilic compound. … [A259746] Because it is a completely non-aqueous liquid, microbial growth is not possible; therefore, its drug products do not need to be combined with any preservative.
Sumatriptan
go.drugbank.com/drugs/DB00669ApprovedInvestigational[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. … Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.
Synonyms: (3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide, 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamideProducts: Imitrex Inj 12mg/ml, SUMATRIPTAN AL 50MG FTAIsavuconazonium
go.drugbank.com/drugs/DB06636ApprovedInvestigational[A38834] It is the prodrug form of isavuconazole, the active moiety, and it is available in oral and parenteral formulations. … Due to low solubility in water of isavuconazole on its own, the isovuconazonium formulation is favorable as it has high solubility in water and allows for intravenous administration.
Tozinameran
go.drugbank.com/drugs/DB15696ApprovedInvestigational[A225386,L15007] Comirnaty is undergoing evaluation in clinical trials in both the USA (NCT04368728) and Germany (NCT04380701). … [L15002] The modRNA is formulated in lipid nanoparticles for administration via intramuscular injection in two doses, three weeks apart.
Pimavanserin
go.drugbank.com/drugs/DB05316ApprovedInvestigationalIn fact, pimavanserin is the first antipsychotic drug without D<sub>2</sub> blocking activity. … [L48236] Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors.
Pexidartinib
go.drugbank.com/drugs/DB12978ApprovedInvestigational[A182243] Pexidartinib is available in oral formulations and it is commonly marketed as Turalio.[L7901] … In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT.
Carbon monoxide
go.drugbank.com/drugs/DB11588ApprovedInvestigationalIt is toxic to hemoglobin utilizing animals (including humans), when encountered in concentrations above about 35 ppm, although it is also formed in normal animal metabolism in low quantities, and is thought … In New Zealand, the use of carbon monoxide in fish preparation has been banned, as it may mask the effects of food spoilage and bacterial growth [L2539].
Synonyms: carbon(II) oxide