Vibrio cholerae CVD 103-HgR strain live antigen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Vaxchora
Generic Name
Vibrio cholerae CVD 103-HgR strain live antigen
DrugBank Accession Number
DB14443
Background

Vibrio cholerae CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against Vibrio cholerae serogroup O1.1

Type
Biotech
Groups
Approved, Investigational
Biologic Classification
Vaccines
Other vaccines
Synonyms
  • Cholera Vaccine
  • Cholera Vaccine Live Oral
  • Cholera vaccine, live, oral

Pharmacology

Indication

Vibrio cholerae CVD 103-HgR strain live antigen is indicated for active oral immunization against infection caused by Vibrio cholerae serogroup O1 in patients between 18 and 64 years of age.1

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirThe therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Abacavir.
AbataceptThe risk or severity of infection can be increased when Vibrio cholerae CVD 103-HgR strain live antigen is combined with Abatacept.
Acetic acidThe therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Acetic acid.
Acetyl sulfisoxazoleThe therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Acetyl sulfisoxazole.
AcyclovirThe therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Acyclovir.
AdalimumabThe risk or severity of infection can be increased when Vibrio cholerae CVD 103-HgR strain live antigen is combined with Adalimumab.
Adefovir dipivoxilThe therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Adefovir dipivoxil.
AldesleukinThe risk or severity of infection can be increased when Vibrio cholerae CVD 103-HgR strain live antigen is combined with Aldesleukin.
AlefaceptThe risk or severity of infection can be increased when Vibrio cholerae CVD 103-HgR strain live antigen is combined with Alefacept.
AlemtuzumabThe risk or severity of infection can be increased when Vibrio cholerae CVD 103-HgR strain live antigen is combined with Alemtuzumab.
Interactions
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Food Interactions
  • Take separate from meals. Oral cholera vaccines should be administered on an empty stomach. Avoid food or drink for 60 minutes before and after administration.

Products

Products
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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Cholera Vaccine Strain 35a-and 41 8000m/ccSuspension8000 m / mLSubcutaneousAventis Pasteur Limited1942-12-312001-07-19Canada flag
VaxchoraKit1200000000 [CFU]/1OralPaxvax, Inc.2016-10-03Not applicableUS flag
Vaxchora400000000 CFUOralEmergent Netherlands B.V.2020-12-21Not applicableEU flag
VaxchoraKit1200000000 [CFU]/1OralEmergent Travel Health Inc.2020-02-13Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
V9G528E9E0
CAS number
1704499-30-8

References

General References
  1. FDA Approved Drug Products: Vaxchora (cholera vaccine, live, oral) oral suspension [Link]
RxNav
1812935

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionCholera2
4CompletedPreventionCholera (Disorder)1
4CompletedPreventionCholera / Vibrio Cholerae1
4CompletedPreventionCholera / Vibrio Cholerae Infection1
4CompletedPreventionVibrio Cholerae1
4RecruitingBasic ScienceCholera Vaccination1
4RecruitingBasic ScienceTyphoid and/or Cholera Vaccination1
3CompletedPreventionCholera1
3CompletedPreventionCholera / Diarrhoea / Vibrio Infections1
3CompletedPreventionPrevention Harmful Effects1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SuspensionSubcutaneous8000 m / mL
KitOral1200000000 [CFU]/1
Powder, for suspensionOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on July 05, 2018 18:02 / Updated on June 12, 2020 16:53