Vibrio cholerae CVD 103-HgR strain live antigen is a live, attenuated vaccine indicated for active immunization against disease caused by Vibrio cholerae serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by Vibrio cholerae, which is gram-negative bacteria.
- Mechanism
- Curator reviewed · 4 references
Vibrio cholerae CVD 103-HgR strain live antigen contains live attenuated cholera bacteria (V. cholerae O1 classical Inaba strain CVD 103- HgR). As an oral vaccine, it works by mimicking the natural infection of V. cholerae to generate a mucosal gut immune response. Upon administration, live attenuate cholera bacteria replicate in the gastrointestinal tract, thereby inducing rapid serum vibriocidal antibody and memory B cell responses. However, the exact immune mechanisms that lead to protection against cholera are not yet determined. Compared to killed bacterial strains, live strains are more efficiently taken up by M cells in the intestine, which are the major antigen sampling cells in the gut.
- Primary indication
- Vibrio cholerae CVD 103-HgR strain live antigen is indicated for active oral immunization against infection caused by Vibrio cholerae serogroup O1 in patients between 2 and 64 years of age.Curator reviewed · 1 structured indication
- First approval
- Canada, 2000 · United States, 2016 · European Union, 2020
- Also known as
- Cholera Vaccine · Cholera Vaccine Live Oral · Cholera vaccine, live, oral
- Brand names
Resolves to
What you can answer from here — as of May 03, 2025
Which other approved drugs treat the same conditions as Vibrio cholerae CVD 103-HgR strain live antigen, and which companies have late-stage candidates in those indications?
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