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Pozelimab
go.drugbank.com/drugs/DB15218ApprovedInvestigationalCD55-deficient protein-losing enteropathy (PLE), or CHAPLE disease, is an ultra-rare hereditary disease, with fewer than 100 patients diagnosed worldwide or fewer than 10 patients in the US. … [A261120] Pozelimab is a human, monoclonal immunoglobulin G4<sup>P</sup> antibody against the terminal complement protein C5.
Tenocyclidine
go.drugbank.com/drugs/DB01520IllicitInvestigationalTenocyclidine (TCP, thienyl cyclohexylpiperidine) is a dissociative anesthetic drug with stimulant and hallucinogenic effects.
Categories: Compounds used in a research, industrial, or household settingIsoflurophate
go.drugbank.com/drugs/DB00677ApprovedWithdrawnAn irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma.
Synonyms: O,O'-diisopropyl phosphoryl fluorideFilgotinib
go.drugbank.com/drugs/DB14845ApprovedInvestigationalRheumatoid arthritis (RA) is a chronic, autoimmune, systemic, and inflammatory disease that causes synovial joint symptoms and can limit range of motion in severe cases. … [A189165] Non-selective JAK inhibitors like [tofacitinib] target JAK1 and JAK3 subtypes with minimal activity at JAK2. In contrast, the newly approved filgotinib is a highly selective JAK1 inhibitor.
Oxiconazole
go.drugbank.com/drugs/DB00239ApprovedIt is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin infections such as athlete's foot, jock itch and ringworm. … Oxiconazole is an antifungal agent that is commonly found in topical formulations.
Categories: combinations of imidazole derivativesSynonyms: 2',4'-Dichloro-2-imidazol-1-ylacetophenone (Z)-[O-(2,4-dichlorobenzyl)oxime]Omadacycline
go.drugbank.com/drugs/DB12455ApprovedInvestigationalclasses of antibiotics and known to cause diseases such as pneumonias, urinary tract infections, skin diseases and blood-borne infections in both the hospital and community settings. … Omadacycline represents a significant advance over the well-known tetracycline family, and has been shown to be highly effective in animal models at treating increasingly problematic, clinically prevalent
Categories: combinations of tetracyclinesRoxatidine acetate
go.drugbank.com/drugs/DB08806InvestigationalRoxatidine acetate is a specific and competitive H2 receptor antagonist. It is currently approved in South Africa under the tradename Roxit.
Safrazine
go.drugbank.com/drugs/DB09253ApprovedWithdrawnSafrazine is a member of the hydrazine family with non-selective and irreversible inhibitor effects against monoamine oxidases. In 1960, it was used as an antidepressant but it is now discontinued.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeMeticillin
go.drugbank.com/drugs/DB01603ApprovedInvestigationalOne of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Categories: combinations of penicillinsEplontersen
go.drugbank.com/drugs/DB16199ApprovedInvestigational+7) and the Norfolk Quality of Life Questionnaire-Diabetic Neuropathy (Norfolk QoL-DN) Score were observed. … [A262985] As eplontersen targets both the WT and mutant TTR, it poses tremendous promises as a treatment.