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Eltrapuldencel-T
go.drugbank.com/drugs/DB17329InvestigationalSynonyms: Autologous dendritic cells loaded with antigen from self-renewing, proliferating autologous irradiated tumour cells, in a solution of granulocyte-macrophage colony stimulating factor (GM-CSF), Eltrapuldencel-TCilofexor
go.drugbank.com/drugs/DB15168InvestigationalCilofexor is under investigation in clinical trial NCT02943447 (Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis).
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acidNutlin-3
go.drugbank.com/drugs/DB17039ExperimentalNutlin-3 is a small molecule inhibitor that targets p53-Mdm2 interaction.[A253057]
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-piperazinone, 4-(((4r,5s)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1h-imidazol-1-yl)carbonyl)-, rel-, Nutlin-3TSN-084
go.drugbank.com/drugs/DB18306InvestigationalSynonyms: 3-PYRIDINECARBOXAMIDE, N-(3-FLUORO-4-((1-METHYL-6-(1H-PYRAZOL-4-YL)-1H-INDAZOL-5-YL)OXY)PHENYL)-1-(4-FLUOROPHENYL)-1,2-DIHYDRO-6-(1-METHYLETHOXY)-2-OXO-, N-[3-fluoro-4-[[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy]phenyl]-1-(4-fluorophenyl)-1,2-dihydro-6-(1-methylethoxy)-2-oxo-3-pyridinecarboxamideZinc dibutyldithiocarbamate
go.drugbank.com/drugs/DB14194ApprovedZinc dibutyldithiocarbamate is a dermatological sensitizer and allergen. Sensitivity to zinc dibutyldithiocarbamate may be identified with a clinical patch test.
Synonyms: (T-4)-bis(dibutylcarbamodithioato-κS,κS')zincTolmetin
go.drugbank.com/drugs/DB00500ApprovedA non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-RingSynonyms: 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid, 1-Methyl-5-p-toluoylpyrrole-2-acetic acidSerplulimab
go.drugbank.com/drugs/DB17451ApprovedInvestigationalSerplulimab is a humanized monoclonal IgG4 antibody that acts as an immune checkpoint inhibitor by targeting the programmed cell death-1 (PD-1) receptor. … It was first approved in China - where it is indicated for a number of different cancers[L52963] - and has since been approved in several southeast Asian countries.
Synonyms: Immunoglobulin g4 (228-proline), anti-(human programmed cell death protein 1) (human-mus musculus monoclonal hlx10 .gamma.4-chain), disulfide with human-mus musculus monoclonal hlx10 .kappa.Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsMotolimod
go.drugbank.com/drugs/DB12303InvestigationalMotolimod has been used in trials studying the treatment of Lymphoma, Tongue Cancer, Ovarian Cancer, Adult Solid Neoplasm, and Fallopian Tube Cancer, among others.
Categories: Heterocyclic Compounds, 2-Ring, Toll-Like Receptor 8, agonistsSynonyms: {2-amino-8-[4-(pyrrolidinylcarbonyl)phenyl](3H-benzo[f]azepin-4-yl)}-N,N-dipropycarboxamideATG-101
go.drugbank.com/drugs/DB17162InvestigationalATG-101 is a novel PD-L1/4-1BB bispecific antibody that was designed to block the binding of immunosuppressive PD-1/PD-L1 and conditionally induce 4-1BB stimulation, thus activating anti-tumor immune effectors … , while delivering enhanced anti-tumor activity, with an improved safety profile.
Synonyms: PD-L1/4-1BB bispecific antibodyCXD101
go.drugbank.com/drugs/DB16182InvestigationalCXD101 is under investigation in clinical trial NCT03873025 (A Study of CXD101 in Combination With Pembrolizumab for Relapsed or Refractory Diffuse Large B-cell Lymphoma).
Synonyms: Hdac-in-4