Cilofexor

DB15168InvestigationalSmall molecule

Cilofexor is under investigation in clinical trial NCT02943447 (Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary Cholangitis Without Cirrhosis).

Mechanism: Pharmacologically active on Bile acid receptor
Curator reviewed
Formula / weight: C₂₈H₂₂Cl₃N₃O₅ · 586.85 g/mol (avg)
Also known as: 2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid
Code names: GS-9674

Resolves to

Compound

UNIIYUN2306954CAS1418274-28-8ChEMBLCHEMBL4297613

Structure

InChIKeyKZSKGLFYQAYZCO-UHFFFAOYSA-NSMILESOC(=O)C1=CC=NC(=C1)N1CC(O)(C1)C1=C(Cl)C=C(OCC2=C(ON=C2C2=C(Cl)C=CC=C2Cl)C2CC2)C=C1

Targets

Q96RI1NR1H4

What you can answer from here — as of September 12, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

8Clinical trialsPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Cilofexor, and which of those have an active Phase 3 trial?

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