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Finerenone
go.drugbank.com/drugs/DB16165ApprovedInvestigational[A236544] Spironolactone has low selectivity and affinity for the receptor; it dissociates quickly and can also have effects at the androgen, progesterone, and glucocorticoid receptors. … [A236544,L34739] Finerenone was granted FDA approval on 9 July 2021,[L34739] followed by the EMA approval on 11 March 2022.[L41449]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesBrilliant green cation
go.drugbank.com/drugs/DB11279ApprovedVet approvedDue to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and swabs used to prevent infection. … Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and wool.
Mixtures: Kerr 100 Triple Dye Dispos-ACategories: Compounds used in a research, industrial, or household settingDimazole
go.drugbank.com/drugs/DB13858ApprovedWithdrawnDimazole (diamthazole) is an antifungal. It was withdrawn in Franch in 1972 due to neuropsychiatric reactions.
Categories: Heterocyclic Compounds, 1-RingQuinestrol
go.drugbank.com/drugs/DB04575ApprovedThe 3-cyclopentyl ether of ethinyl estradiol.
Synonyms: Estradiol-17-beta 3-cyclopentyl ether, 17-alpha-Ethinylestradiol 3-cyclopentyl etherMalate dehydrogenase, cytoplasmic
go.drugbank.com/bio_entities/BE0000589TargetHumansCatalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply...
Synonyms: KAROxaprozin
go.drugbank.com/drugs/DB00991ApprovedOxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-RingProducts: DILOX®, DURAPROX®Tirbanibulin
go.drugbank.com/drugs/DB06137ApprovedInvestigational[L27806] Actinic keratosis is a chronic condition characterized by lesions, which can potentially transform into invasive squamous cell carcinoma with a risk of 1% over 10 years. … Tirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsPlacental Mesenchymal Stem Cells
go.drugbank.com/drugs/DB15730InvestigationalThe placenta serves many purposes, with one of the many being a bank of mesenchymal stem cells (MSCs). … It can be obtained relatively easily as medical waste from which MSCs can be non-invasively extracted and without the ethical issues that come with embryonic stem cells.
Momelotinib
go.drugbank.com/drugs/DB11763ApprovedInvestigationalMomelotinib is a Janus Kinase 1 (JAK1) and 2 (JAK2) inhibitor. It is a competitive inhibitor of JAK ATP binding. … [L48186] Myelofibrosis (MF) is a group of myeloproliferative neoplasms characterized by abnormal proliferative hematopoietic stem cells, leading to the release of cytokines and growth factors.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: N-(CYANOMETHYL)-4-(2-(4-MORPHOLINOANILINO)PYRIMIDIN-4-YL)BENZAMIDESMAD family member 2
go.drugbank.com/bio_entities/BE0004445TargetHumansMay act as a tumor suppressor in colorectal carcinoma (PubMed:8752209) … Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription.
Synonyms: MAD homolog 2, Mad-related protein 2