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Amifampridine
go.drugbank.com/drugs/DB11640ApprovedAbout 50-60% of the patients develop more rapidly progressive LEMS and small cell lung cancer, which influences the prognosis [A33863]. … Amifampridine phosphate is a more stable salt that serves as an active ingredient of EMA-approved Firdapse, which was previously marketed as Zenas.
Samidorphan
go.drugbank.com/drugs/DB12543ApprovedInvestigational, and a longer half-life, making it an attractive candidate for oral dosing. … [A235638, A235643] Samidorphan is a novel opioid antagonist structurally related to [naltrexone], with a higher affinity for opioid receptors, more potent μ-opioid receptor antagonism, higher oral bioavailability
Salts: Samidorphan L-malateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCarfentanil
go.drugbank.com/drugs/DB01535IllicitInvestigationalVet approvedIt has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl, with activity in humans starting at about 1 microgram. … It is marketed under the trade name Wildnil as a general anaesthetic agent for large animals.
Ethinamate
go.drugbank.com/drugs/DB01031ApprovedIllicitWithdrawnEthinamate is a short-acting sedative-hypnotic medication used to treat insomnia. … Like many such similar medications, the regular use of ethinamate can result in the development of drug tolerance in a patient.
De Novo Triacylglycerol Biosynthesis TG(15:0/18:1(9Z)/24:1(15Z))
smpdb.ca/view/SMP0017189MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
Phosphatidylethanolamine Biosynthesis PE(15:0/20:4(5Z,8Z,11Z,13E)-OH(15S))
smpdb.ca/view/SMP0127140MetabolicPhosphatidylethanolamines (PE) are a class of phospholipids that incorporate a phosphoric acid headgroup into a diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and contrary to phospha...
Phosphatidylethanolamine Biosynthesis PE(20:3(5Z,8Z,11Z)-O(14R,15S)/15:0)
smpdb.ca/view/SMP0127380MetabolicPhosphatidylethanolamines (PE) are a class of phospholipids that incorporate a phosphoric acid headgroup into a diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and contrary to phospha...
Phosphatidylethanolamine Biosynthesis PE(20:4(5Z,8Z,11Z,13E)-OH(15S)/15:0)
smpdb.ca/view/SMP0127434MetabolicPhosphatidylethanolamines (PE) are a class of phospholipids that incorporate a phosphoric acid headgroup into a diacylglycerol backbone. They are the second most abundant phospholipid in eukaryotic cell membranes, and contrary to phospha...
De Novo Triacylglycerol Biosynthesis TG(15:0/22:1(13Z)/24:1(15Z))
smpdb.ca/view/SMP0017265MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(15:0/24:1(15Z)/14:1(9Z))
smpdb.ca/view/SMP0017284MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...