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Gepotidacin
go.drugbank.com/drugs/DB12134ApprovedInvestigational[A273755] By inhibiting two distinct bacterial enzymes, a lower potential for the development of resistance to gepotidacin is expected. … Gepotidacin is a first-in-class triazaacenaphthylene antibacterial targeting bacterial DNA gyrase and topoisomerase IV.[L52685] Its target is similar to that of fluoroquinolone antibacterials - e.g.
Cocamidopropyl betaine
go.drugbank.com/drugs/DB11350ApprovedCocamidopropyl betaine is a mixture of closely related organic compounds derived from coconut oil and dimethylaminopropylamine that typically acts as an amphoteric surfactant in cosmetics and personal … Impurities formed during the manufacturing process are thought to increase the prevalence of contact sensitization and mild skin irritations.
Categories: Compounds used in a research, industrial, or household settingGadodiamide
go.drugbank.com/drugs/DB00225ApprovedInvestigationalGadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels. … [A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents.
Categories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of ChemicalsMefloquine
go.drugbank.com/drugs/DB00358Approved[A226838] This drug has been the subject of widespread controversy due to concerns regarding neurotoxic effects; product information warns of potential serious neuropsychiatric effects.[A226838,L8953] … Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world.
Synonyms: (DL-ERYTHRO-.ALPHA.-2-PIPERIDYL-2,8-BIS(TRIFLUOROMETHYL)-4-QUINOLINEMETHANOLFidaxomicin
go.drugbank.com/drugs/DB08874ApprovedInvestigational[A190492] Unlike vancomycin, however, fidaxomicin has a negligible effect on normal colonic microflora. … Fidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by _Clostridioides_ (formerly _Clostridium_) _difficile_ in adult and pediatric patients over the age of 6 months.
Teplizumab
go.drugbank.com/drugs/DB06606ApprovedInvestigationalTeplizumab was designed as an Fc-non-binding antibody in order to reduce the incidence of CRS. … [A241480] On November 2022, teplizumab was approved by the FDA as the first drug that can delay the onset of type 1 diabetes.
Iopanoic acid
go.drugbank.com/drugs/DB08946ApprovedWithdrawnIopanoic acid contains iodine and is useful as a contrast medium in cholecystography.
Categories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of ChemicalsFlavin adenine dinucleotide
go.drugbank.com/drugs/DB03147ApprovedA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. … (Lehninger, Principles of Biochemistry, 1982, p972) Flavin adenine dinucleotide is approved for use in Japan under the trade name Adeflavin as an ophthalmic treatment for vitamin B2 deficiency.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesTremelimumab
go.drugbank.com/drugs/DB11771ApprovedInvestigationalCTLA-4 is a cell surface receptor expressed on activated T cells to act as a negative regulator for T cells. … [A253717] By binding to CTLA-4, tremelimumab enhances T cell-mediated killing of tumours and reduces tumour growth.
Dimazole
go.drugbank.com/drugs/DB13858ApprovedWithdrawnDimazole (diamthazole) is an antifungal. It was withdrawn in Franch in 1972 due to neuropsychiatric reactions.