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Amoxapine
go.drugbank.com/drugs/DB00543ApprovedSee toxicity section below for a complete listing of side effects. … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation.
Categories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexPurslane
go.drugbank.com/drugs/DB14327ApprovedPurslane is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Ceftobiprole medocaril
go.drugbank.com/drugs/DB14733ApprovedCeftobiprole medocaril is a prodrug of [ceftobiprole], a fifth-generation semisynthetic cephalosporin antibacterial. … Ceftobiprole is a broad-spectrum agent with demonstrated activity against both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains of _Staphylcoccus aureus_ (methicillin-resistant
Talimogene laherparepvec
go.drugbank.com/drugs/DB13896ApprovedInvestigationalIt is a genetically administered herpes simplex virus 1 (HSV-1) that expresses human cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with antitumor and immune-stimulating activities. … It specifically replicates within tumor cells and causes lysis. It was approved by the FDA in 2015 under the market name Imlygic.
Synonyms: T Vec, T-VecThyroid, porcine
go.drugbank.com/drugs/DB09100ApprovedInvestigational[A190831] Thyroid extract is no longer considered a first line therapy as it delivers a dose that is inconsistent with the stated strength of the tablet. … [A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891[A190807] but its use dates back as far as the 6th century.
Zafirlukast
go.drugbank.com/drugs/DB00549ApprovedIt is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily. … Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator.
Caplacizumab
go.drugbank.com/drugs/DB06081ApprovedInvestigationalCaplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019,[L5302] and approved previously by the EU in October 2018 as a combination therapy with plasma exchange and immunosuppression … Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker.
Canakinumab
go.drugbank.com/drugs/DB06168ApprovedInvestigationalBoth heavy chains of canakinumab contain oligosaccharide chains linked to the protein backbone at asparagine 298 (Asn 298). … It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated.
Omidubicel
go.drugbank.com/drugs/DB17132ApprovedInvestigationalIt is administered as a single intravenous dose specific to each patient. … Omidubicel is a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy derived from cord blood used as an allogeneic stem cell donor source.
Pentaerythritol tetranitrate
go.drugbank.com/drugs/DB06154ApprovedWithdrawnWhen mixed with a plasticizer, this chemical forms a plastic explosive. It is recognized by the FDA to be a coronary vasodilator in the treatment of heart conditions such as angina [L2395]. … It is then filtered out, washed, dried, and recrystallized to produce a colorless crystalline material that is stored and shipped as a mixture with water and alcohol [L2394].