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Triamterene
go.drugbank.com/drugs/DB00384ApprovedTriamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the d...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesNimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalNimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in sm...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: NIMODIPINA DOC GENERICI, NIMODIPINA MYLAN GENERICSBeclomethasone dipropionate
go.drugbank.com/drugs/DB00394ApprovedInvestigationalBeclomethasone dipropionate is a second-generation synthetic corticosteroid and diester of beclomethasone, which is structurally similar to dexamethasone. It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP) ...
Categories: P-glycoprotein inducers, P-glycoprotein substratesProducts: BECLOMETASONE DOC GENERICILoxapine
go.drugbank.com/drugs/DB00408ApprovedInvestigationalAn antipsychotic agent used in schizophrenia. [PubChem]
Categories: P-glycoprotein inhibitorsAcetohexamide
go.drugbank.com/drugs/DB00414ApprovedWithdrawnA sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Synonyms: 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea, N-(p-Acetylphenylsulfonyl)-N'-cyclohexylureaCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesCefpiramide
go.drugbank.com/drugs/DB00430ApprovedCefpiramide is a third-generation cephalosporin antibiotic.
Prochlorperazine
go.drugbank.com/drugs/DB00433ApprovedInvestigationalVet approvedProchlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such a...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesCerivastatin
go.drugbank.com/drugs/DB00439ApprovedWithdrawnOn August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this chol...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP2B6 InducersGemcitabine
go.drugbank.com/drugs/DB00441ApprovedInvestigationalGemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers. Gemcitabine is a cytidine analog with two fluorin...
Categories: P-glycoprotein substrates, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: GEMCITABINA MYLAN GENERICSTeniposide
go.drugbank.com/drugs/DB00444ApprovedInvestigationalTeniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and pr...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 Substrates