Cerivastatin is a statin (or HMG CoA reductase inhibitor) used with dietary changes to decrease lipid levels and reduce the risk of cardiovascular events. On August 8, 2001 the U.S.
- Mechanism
- Curator reviewed
Cerivastatin competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the hepatic enzyme responsible for converting HMG-CoA to mevalonate. As mevalonate is a precursor of sterols such as cholesterol, this results in a decrease in cholesterol in hepatic cells, upregulation of LDL-receptors, and an increase in hepatic uptake of LDL-cholesterol from the circulation.
- Primary indication
- Used as an adjunct to diet for the reduction of elevated total and LDL cholesterol levels in patients with primary hypercholesterolemia and mixed dyslipidemia (Fredrickson Types IIa and IIb) when the response to dietary restriction...Curator reviewed
- Formula / weight
- C26H34FNO5 · 459.5503 g/mol (avg)
- First approval
- Canada, 1998
Resolves to
SEERZIQQUAZTOL-ANMDKAQQSA-NSMILESCOCC1=C(C2=CC=C(F)C=C2)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C(C(C)C)N=C1C(C)CWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Cerivastatin, and which of those have an active Phase 3 trial?
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