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Zidovudine
go.drugbank.com/drugs/DB00495ApprovedInvestigationalA dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid c...
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesRitonavir
go.drugbank.com/drugs/DB00503ApprovedInvestigationalRitonavir is an HIV protease inhibitor that interferes with the reproductive cycle of HIV. Although it was initially developed as an independent antiviral agent, it has been shown to possess advantageous properties in combination regimen...
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsAlbendazole
go.drugbank.com/drugs/DB00518ApprovedInvestigationalVet approvedA benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesAlitretinoin
go.drugbank.com/drugs/DB00523ApprovedAn important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess o...
Categories: P-glycoprotein substratesMephenytoin
go.drugbank.com/drugs/DB00532ApprovedWithdrawnMephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesRofecoxib
go.drugbank.com/drugs/DB00533ApprovedWithdrawnRofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belong...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersAmoxapine
go.drugbank.com/drugs/DB00543ApprovedAmoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an a...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesFluorouracil
go.drugbank.com/drugs/DB00544ApprovedInvestigationalA pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesMedroxyprogesterone acetate
go.drugbank.com/drugs/DB00603ApprovedInvestigationalMedroxyprogesterone acetate (MPA) is a progesterone derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesCisapride
go.drugbank.com/drugs/DB00604ApprovedWithdrawnIn many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regardi...
Categories: Serotonin Receptor Agonists, Cytochrome P-450 Substrates