Mephenytoin is a phenylhydantoin used to treat refractory partial epilepsy. This compound belongs to the phenylhydantoins.
- Mechanism
- Curator reviewed
The mechanism of action of mephenytoin is not definitely known, but extensive research strongly suggests that its main mechanism is to block frequency-, use- and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.
- Primary indication
- For the treatment of refractory partial epilepsy.Curator reviewed
- Formula / weight
- C12H14N2O2 · 218.2518 g/mol (avg)
- First approval
- United States, 1946
Resolves to
Clinical / RWD
Structure
InChIKey
GMHKMTDVRCWUDX-UHFFFAOYSA-NSMILESCCC1(NC(=O)N(C)C1=O)C1=CC=CC=C1Targets
What you can answer from here — as of September 23, 2026
3Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
Which drugs share a target with Mephenytoin, and which of those have an active Phase 3 trial?
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